| http://purl.uniprot.org/citations/21966515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21966515 | http://www.w3.org/2000/01/rdf-schema#comment | "We have identified a novel component of the circadian clock that regulates its sensitivity to light at the evening light to dark transition. USP2 (Ubiquitin Specific Protease 2), which de-ubiquitinylates and stabilizes target proteins, is rhythmically expressed in multiple tissues including the SCN. We have developed a knockout model of USP2 and found that exposure to low irradiance light at ZT12 increases phase delays of USP2(-/-) mice compared to wildtype. We additionally show that USP2b is in a complex with several clock components and regulates the stability and turnover of BMAL1, which in turn alters the expression of several CLOCK/BMAL1 controlled genes. Rhythmic expression of USP2 in the SCN and other tissues offers a new level of control of the clock machinery through de-ubiqutinylation and suggests a role for USP2 during circadian adaptation to environmental day length changes."xsd:string |
| http://purl.uniprot.org/citations/21966515 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0025382"xsd:string |
| http://purl.uniprot.org/citations/21966515 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/21966515 | http://purl.uniprot.org/core/author | "Yadav G."xsd:string |
| http://purl.uniprot.org/citations/21966515 | http://purl.uniprot.org/core/author | "Besharse J.C."xsd:string |
| http://purl.uniprot.org/citations/21966515 | http://purl.uniprot.org/core/author | "Fogerty J."xsd:string |
| http://purl.uniprot.org/citations/21966515 | http://purl.uniprot.org/core/author | "Humby M."xsd:string |
| http://purl.uniprot.org/citations/21966515 | http://purl.uniprot.org/core/author | "Scoma H.D."xsd:string |
| http://purl.uniprot.org/citations/21966515 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21966515 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/21966515 | http://purl.uniprot.org/core/pages | "e25382"xsd:string |
| http://purl.uniprot.org/citations/21966515 | http://purl.uniprot.org/core/title | "The de-ubiquitinylating enzyme, USP2, is associated with the circadian clockwork and regulates its sensitivity to light."xsd:string |
| http://purl.uniprot.org/citations/21966515 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/21966515 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21966515 |
| http://purl.uniprot.org/citations/21966515 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21966515 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SUT8-mappedCitation-21966515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21966515 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VHL1-mappedCitation-21966515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21966515 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VI54-mappedCitation-21966515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21966515 |
| http://purl.uniprot.org/uniprot/#_A0A2R8W6S2-mappedCitation-21966515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21966515 |
| http://purl.uniprot.org/uniprot/#_A0A668KLW3-mappedCitation-21966515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21966515 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GS77-mappedCitation-21966515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21966515 |
| http://purl.uniprot.org/uniprot/#_A9J9D8-mappedCitation-21966515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21966515 |
| http://purl.uniprot.org/uniprot/#_B0QZN6-mappedCitation-21966515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21966515 |
| http://purl.uniprot.org/uniprot/#_A5JUZ1-mappedCitation-21966515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21966515 |