| http://purl.uniprot.org/citations/21976511 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21976511 | http://www.w3.org/2000/01/rdf-schema#comment | "Excitatory synaptic transmission stimulates brain tissue glycolysis. This phenomenon is the signal detected in FDG-PET imaging and, through enhanced lactate production, is also thought to contribute to the fMRI signal. Using a method based on Förster resonance energy transfer in mouse astrocytes, we have recently observed that a small rise in extracellular K(+) can stimulate glycolysis by >300% within seconds. The K(+) response was blocked by ouabain, but intracellular engagement of the Na(+)/K(+) ATPase pump with Na(+) was ineffective, suggesting that the canonical feedback regulatory pathway involving the Na(+) pump and ATP depletion is only permissive and that a second mechanism is involved. Because of their predominant K(+) permeability and high expression of the electrogenic Na(+)/HCO(3)(-) cotransporter NBCe1, astrocytes respond to a rise in extracellular K(+) with plasma membrane depolarization and intracellular alkalinization. In the present article, we show that a fast glycolytic response can be elicited independently of K(+) by plasma membrane depolarization or by intracellular alkalinization. The glycolytic response to K(+) was absent in astrocytes from NBCe1 null mice (Slc4a4) and was blocked by functional or pharmacological inhibition of the NBCe1. Hippocampal neurons acquired K(+)-sensitive glycolysis upon heterologous NBCe1 expression. The phenomenon could also be reconstituted in HEK293 cells by coexpression of the NBCe1 and a constitutively open K(+) channel. We conclude that the NBCe1 is a key element in a feedforward mechanism linking excitatory synaptic transmission to fast modulation of glycolysis in astrocytes."xsd:string |
| http://purl.uniprot.org/citations/21976511 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.2310-11.2011"xsd:string |
| http://purl.uniprot.org/citations/21976511 | http://purl.uniprot.org/core/author | "Gutierrez R."xsd:string |
| http://purl.uniprot.org/citations/21976511 | http://purl.uniprot.org/core/author | "Shull G.E."xsd:string |
| http://purl.uniprot.org/citations/21976511 | http://purl.uniprot.org/core/author | "Niemeyer M.I."xsd:string |
| http://purl.uniprot.org/citations/21976511 | http://purl.uniprot.org/core/author | "Barros L.F."xsd:string |
| http://purl.uniprot.org/citations/21976511 | http://purl.uniprot.org/core/author | "Pena-Munzenmayer G."xsd:string |
| http://purl.uniprot.org/citations/21976511 | http://purl.uniprot.org/core/author | "Lerchundi R."xsd:string |
| http://purl.uniprot.org/citations/21976511 | http://purl.uniprot.org/core/author | "Anazco C."xsd:string |
| http://purl.uniprot.org/citations/21976511 | http://purl.uniprot.org/core/author | "Ruminot I."xsd:string |
| http://purl.uniprot.org/citations/21976511 | http://purl.uniprot.org/core/author | "Sotelo-Hitschfeld T."xsd:string |
| http://purl.uniprot.org/citations/21976511 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21976511 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/21976511 | http://purl.uniprot.org/core/pages | "14264-14271"xsd:string |
| http://purl.uniprot.org/citations/21976511 | http://purl.uniprot.org/core/title | "NBCe1 mediates the acute stimulation of astrocytic glycolysis by extracellular K+."xsd:string |
| http://purl.uniprot.org/citations/21976511 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/21976511 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21976511 |
| http://purl.uniprot.org/citations/21976511 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21976511 |
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