| http://purl.uniprot.org/citations/21976679 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21976679 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-2 is a key cytokine during proliferation and activation of T lymphocytes and functions as an auto- and paracrine growth factor. Regardless of activating effects on T lymphocytes, the absence of IL-2 has been linked to the development of autoimmune pathology in mice and humans. Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease and characterized by dysregulation of lymphocyte function, transcription factor and cytokine expression, and antigen presentation. Reduced IL-2 expression is a hallmark of SLE T lymphocytes and results in decreased numbers of regulatory T lymphocytes which play an important role in preventing autoimmunity. Reduced IL-2 expression was linked to overproduction of the transcription regulatory factor cAMP-responsive element modulator (CREM)α in SLE T lymphocytes and subsequent CREMα binding to a CRE site within the IL2 promoter (-180 CRE). In this study, we demonstrate the involvement of CREMα-mediated IL2 silencing in T lymphocytes from SLE patients through a gene-wide histone deacetylase 1-directed deacetylation of histone H3K18 and DNA methyltransferase 3a-directed cytosine phosphate guanosine (CpG)-DNA hypermethylation. For the first time, we provide direct evidence that CREMα mediates silencing of the IL2 gene in SLE T cells though histone deacetylation and CpG-DNA methylation."xsd:string |
| http://purl.uniprot.org/citations/21976679 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m111.299339"xsd:string |
| http://purl.uniprot.org/citations/21976679 | http://purl.uniprot.org/core/author | "Tsokos G.C."xsd:string |
| http://purl.uniprot.org/citations/21976679 | http://purl.uniprot.org/core/author | "Hedrich C.M."xsd:string |
| http://purl.uniprot.org/citations/21976679 | http://purl.uniprot.org/core/author | "Rauen T."xsd:string |
| http://purl.uniprot.org/citations/21976679 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21976679 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/21976679 | http://purl.uniprot.org/core/pages | "43429-43436"xsd:string |
| http://purl.uniprot.org/citations/21976679 | http://purl.uniprot.org/core/title | "cAMP-responsive element modulator (CREM)alpha protein signaling mediates epigenetic remodeling of the human interleukin-2 gene: implications in systemic lupus erythematosus."xsd:string |
| http://purl.uniprot.org/citations/21976679 | http://purl.uniprot.org/core/volume | "286"xsd:string |
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