| http://purl.uniprot.org/citations/21980415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21980415 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21980415 | http://www.w3.org/2000/01/rdf-schema#comment | "Here we identified an evolutionarily highly conserved and ubiquitously expressed protein (C9orf82) that shows structural similarities to the death effector domain of apoptosis-related proteins. RNAi knockdown of C9orf82 induced apoptosis in A-549 and MCF7/casp3-10b lung and breast carcinoma cells, respectively, but not in cells lacking caspase-3, caspase-10 or both. Apoptosis was associated with activated caspases-3, -8, -9 and -10, and inactivation of caspases 10 or 3 was sufficient to block apoptosis in this pathway. Apoptosis upon knockdown of C9orf82 was associated with increased caspase-10 expression and activation, which was required for the generation of an 11 kDa tBid fragment and activation of Caspase-9. These data suggest that C9orf82 functions as an anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop. We designate this ubiquitously expressed and evolutionarily conserved anti-apoptotic protein Conserved Anti-Apoptotic Protein (CAAP). We also demonstrated that treatment of MCF7/casp3-10b cells with staurosporine and etoposides induced apoptosis and knockdown of CAAP expression. This implies that the CAAP protein could be a target for chemotherapeutic agents."xsd:string |
| http://purl.uniprot.org/citations/21980415 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0025284"xsd:string |
| http://purl.uniprot.org/citations/21980415 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0025284"xsd:string |
| http://purl.uniprot.org/citations/21980415 | http://purl.uniprot.org/core/author | "Meller J."xsd:string |
| http://purl.uniprot.org/citations/21980415 | http://purl.uniprot.org/core/author | "Meller J."xsd:string |
| http://purl.uniprot.org/citations/21980415 | http://purl.uniprot.org/core/author | "Miller M.L."xsd:string |
| http://purl.uniprot.org/citations/21980415 | http://purl.uniprot.org/core/author | "Miller M.L."xsd:string |
| http://purl.uniprot.org/citations/21980415 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/21980415 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/21980415 | http://purl.uniprot.org/core/author | "Ferguson D.J."xsd:string |
| http://purl.uniprot.org/citations/21980415 | http://purl.uniprot.org/core/author | "Ferguson D.J."xsd:string |
| http://purl.uniprot.org/citations/21980415 | http://purl.uniprot.org/core/author | "Johansson E."xsd:string |
| http://purl.uniprot.org/citations/21980415 | http://purl.uniprot.org/core/author | "Johansson E."xsd:string |
| http://purl.uniprot.org/citations/21980415 | http://purl.uniprot.org/core/author | "Anderson M.W."xsd:string |
| http://purl.uniprot.org/citations/21980415 | http://purl.uniprot.org/core/author | "Anderson M.W."xsd:string |
| http://purl.uniprot.org/citations/21980415 | http://purl.uniprot.org/core/author | "Janicke R.U."xsd:string |
| http://purl.uniprot.org/citations/21980415 | http://purl.uniprot.org/core/author | "Janicke R.U."xsd:string |
| http://purl.uniprot.org/citations/21980415 | http://purl.uniprot.org/core/author | "Plas D."xsd:string |
| http://purl.uniprot.org/citations/21980415 | http://purl.uniprot.org/core/author | "Plas D."xsd:string |
| http://purl.uniprot.org/citations/21980415 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21980415 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21980415 | http://purl.uniprot.org/core/name | "PLoS ONE"xsd:string |
| http://purl.uniprot.org/citations/21980415 | http://purl.uniprot.org/core/name | "PLoS ONE"xsd:string |