| http://purl.uniprot.org/citations/21981922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21981922 | http://www.w3.org/2000/01/rdf-schema#comment | "General discard pathways eliminate unprocessed and irregular pre-mRNAs to control the quality of gene expression. In contrast to such general pre-mRNA decay, we describe here a nuclear pre-mRNA degradation pathway that controls the expression of select intron-containing genes. We show that the fission yeast nuclear poly(A)-binding protein, Pab2, and the nuclear exosome subunit, Rrp6, are the main factors involved in this polyadenylation-dependent pre-mRNA degradation pathway. Transcriptome analysis and intron swapping experiments revealed that inefficient splicing is important to dictate susceptibility to Pab2-dependent pre-mRNA decay. We also show that negative splicing regulation can promote the poor splicing efficiency required for this pre-mRNA decay pathway, and in doing so, we identified a mechanism of cross-regulation between paralogous ribosomal proteins through nuclear pre-mRNA decay. Our findings unveil a layer of regulation in the nucleus in which the turnover of specific pre-mRNAs, besides the turnover of mature mRNAs, is used to control gene expression."xsd:string |
| http://purl.uniprot.org/citations/21981922 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2011.06.035"xsd:string |
| http://purl.uniprot.org/citations/21981922 | http://purl.uniprot.org/core/author | "Lemieux C."xsd:string |
| http://purl.uniprot.org/citations/21981922 | http://purl.uniprot.org/core/author | "Bachand F."xsd:string |
| http://purl.uniprot.org/citations/21981922 | http://purl.uniprot.org/core/author | "Marguerat S."xsd:string |
| http://purl.uniprot.org/citations/21981922 | http://purl.uniprot.org/core/author | "Bahler J."xsd:string |
| http://purl.uniprot.org/citations/21981922 | http://purl.uniprot.org/core/author | "Barbezier N."xsd:string |
| http://purl.uniprot.org/citations/21981922 | http://purl.uniprot.org/core/author | "Lafontaine J."xsd:string |
| http://purl.uniprot.org/citations/21981922 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21981922 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/21981922 | http://purl.uniprot.org/core/pages | "108-119"xsd:string |
| http://purl.uniprot.org/citations/21981922 | http://purl.uniprot.org/core/title | "A Pre-mRNA degradation pathway that selectively targets intron-containing genes requires the nuclear poly(A)-binding protein."xsd:string |
| http://purl.uniprot.org/citations/21981922 | http://purl.uniprot.org/core/volume | "44"xsd:string |
| http://purl.uniprot.org/citations/21981922 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21981922 |
| http://purl.uniprot.org/citations/21981922 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21981922 |
| http://purl.uniprot.org/uniprot/#_P52808-mappedCitation-21981922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21981922 |
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| http://purl.uniprot.org/uniprot/#_Q9UTN3-mappedCitation-21981922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21981922 |
| http://purl.uniprot.org/uniprot/#_Q9UTP0-mappedCitation-21981922 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21981922 |
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