| http://purl.uniprot.org/citations/21983565 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21983565 | http://www.w3.org/2000/01/rdf-schema#comment | "A hallmark of polarized cells is the segregation of the PAR polarity regulators into asymmetric domains at the cell cortex. Antagonistic interactions involving two conserved kinases, atypical protein kinase C (aPKC) and PAR-1, have been implicated in polarity maintenance, but the mechanisms that initiate the formation of asymmetric PAR domains are not understood. Here, we describe one pathway used by the sperm-donated centrosome to polarize the PAR proteins in Caenorhabditis elegans zygotes. Before polarization, cortical aPKC excludes PAR-1 kinase and its binding partner PAR-2 by phosphorylation. During symmetry breaking, microtubules nucleated by the centrosome locally protect PAR-2 from phosphorylation by aPKC, allowing PAR-2 and PAR-1 to access the cortex nearest the centrosome. Cortical PAR-1 phosphorylates PAR-3, causing the PAR-3-aPKC complex to leave the cortex. Our findings illustrate how microtubules, independently of actin dynamics, stimulate the self-organization of PAR proteins by providing local protection against a global barrier imposed by aPKC."xsd:string |
| http://purl.uniprot.org/citations/21983565 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb2354"xsd:string |
| http://purl.uniprot.org/citations/21983565 | http://purl.uniprot.org/core/author | "Motegi F."xsd:string |
| http://purl.uniprot.org/citations/21983565 | http://purl.uniprot.org/core/author | "Hao Y."xsd:string |
| http://purl.uniprot.org/citations/21983565 | http://purl.uniprot.org/core/author | "Seydoux G."xsd:string |
| http://purl.uniprot.org/citations/21983565 | http://purl.uniprot.org/core/author | "Griffin E."xsd:string |
| http://purl.uniprot.org/citations/21983565 | http://purl.uniprot.org/core/author | "Zonies S."xsd:string |
| http://purl.uniprot.org/citations/21983565 | http://purl.uniprot.org/core/author | "Cuenca A.A."xsd:string |
| http://purl.uniprot.org/citations/21983565 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21983565 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/21983565 | http://purl.uniprot.org/core/pages | "1361-1367"xsd:string |
| http://purl.uniprot.org/citations/21983565 | http://purl.uniprot.org/core/title | "Microtubules induce self-organization of polarized PAR domains in Caenorhabditis elegans zygotes."xsd:string |
| http://purl.uniprot.org/citations/21983565 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/21983565 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21983565 |
| http://purl.uniprot.org/citations/21983565 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21983565 |
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