| http://purl.uniprot.org/citations/21984702 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21984702 | http://www.w3.org/2000/01/rdf-schema#comment | "Cytokine components of Th17 pathway play vital roles in human psoriasis. Although much is known about TCR αβ T cells in psoriasis, the role of unconventional T cells, including γδ T cells, is unclear. In this study, using an IL-23 skin injection model of psoriasiform dermatitis in mice, we demonstrate that IL-22, IL-17A, and the IL-23R were highly enriched in a population of CCR6(+), TCR γδ-low expressing (GDL) T cells that accumulated in the epidermis after IL-23 injections. GDL cells were distinct from resident TCR γδ-high, Vγ3(+),CCR6(-) T cells in the epidermis that did not change appreciably in numbers following IL-23 injection. Large numbers of CCR6(+) cells were detected at or above the level of the epidermal basement membrane by confocal microscopy 5 d after repeated IL-23 injections at the same time GDL cells increased in numbers in the epidermis. TCR δ-deficient mice (lacking γδ T cells) exhibited decreased ear swelling and downregulated expression of IL-22 and IL-17A in the epidermis following IL-23 injection. Our data suggest that a subset of γδ T cells play a critical role in IL-23-mediated psoriasiform dermatitis."xsd:string |
| http://purl.uniprot.org/citations/21984702 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1101817"xsd:string |
| http://purl.uniprot.org/citations/21984702 | http://purl.uniprot.org/core/author | "Mabuchi T."xsd:string |
| http://purl.uniprot.org/citations/21984702 | http://purl.uniprot.org/core/author | "Hwang S.T."xsd:string |
| http://purl.uniprot.org/citations/21984702 | http://purl.uniprot.org/core/author | "Takekoshi T."xsd:string |
| http://purl.uniprot.org/citations/21984702 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21984702 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/21984702 | http://purl.uniprot.org/core/pages | "5026-5031"xsd:string |
| http://purl.uniprot.org/citations/21984702 | http://purl.uniprot.org/core/title | "Epidermal CCR6+ gammadelta T cells are major producers of IL-22 and IL-17 in a murine model of psoriasiform dermatitis."xsd:string |
| http://purl.uniprot.org/citations/21984702 | http://purl.uniprot.org/core/volume | "187"xsd:string |
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