| http://purl.uniprot.org/citations/21993628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21993628 | http://www.w3.org/2000/01/rdf-schema#comment | "Determining the signalling pathways that direct tissue expansion is a principal goal of regenerative biology. Vigorous pancreatic β-cell replication in juvenile mice and humans declines with age, and elucidating the basis for this decay may reveal strategies for inducing β-cell expansion, a long-sought goal for diabetes therapy. Here we show that platelet-derived growth factor receptor (Pdgfr) signalling controls age-dependent β-cell proliferation in mouse and human pancreatic islets. With age, declining β-cell Pdgfr levels were accompanied by reductions in β-cell enhancer of zeste homologue 2 (Ezh2) levels and β-cell replication. Conditional inactivation of the Pdgfra gene in β-cells accelerated these changes, preventing mouse neonatal β-cell expansion and adult β-cell regeneration. Targeted human PDGFR-α activation in mouse β-cells stimulated Erk1/2 phosphorylation, leading to Ezh2-dependent expansion of adult β-cells. Adult human islets lack PDGF signalling competence, but exposure of juvenile human islets to PDGF-AA stimulated β-cell proliferation. The discovery of a conserved pathway controlling age-dependent β-cell proliferation indicates new strategies for β-cell expansion."xsd:string |
| http://purl.uniprot.org/citations/21993628 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature10502"xsd:string |
| http://purl.uniprot.org/citations/21993628 | http://purl.uniprot.org/core/author | "Chen H."xsd:string |
| http://purl.uniprot.org/citations/21993628 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/21993628 | http://purl.uniprot.org/core/author | "Kim S.K."xsd:string |
| http://purl.uniprot.org/citations/21993628 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/21993628 | http://purl.uniprot.org/core/author | "Gu X."xsd:string |
| http://purl.uniprot.org/citations/21993628 | http://purl.uniprot.org/core/author | "Sage J."xsd:string |
| http://purl.uniprot.org/citations/21993628 | http://purl.uniprot.org/core/author | "Schorle H."xsd:string |
| http://purl.uniprot.org/citations/21993628 | http://purl.uniprot.org/core/author | "Bottino R."xsd:string |
| http://purl.uniprot.org/citations/21993628 | http://purl.uniprot.org/core/author | "Wirt S.E."xsd:string |
| http://purl.uniprot.org/citations/21993628 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21993628 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/21993628 | http://purl.uniprot.org/core/pages | "349-355"xsd:string |
| http://purl.uniprot.org/citations/21993628 | http://purl.uniprot.org/core/title | "PDGF signalling controls age-dependent proliferation in pancreatic beta-cells."xsd:string |
| http://purl.uniprot.org/citations/21993628 | http://purl.uniprot.org/core/volume | "478"xsd:string |
| http://purl.uniprot.org/citations/21993628 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21993628 |
| http://purl.uniprot.org/citations/21993628 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21993628 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YUD9-mappedCitation-21993628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21993628 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YV49-mappedCitation-21993628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21993628 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YV87-mappedCitation-21993628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21993628 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GR06-mappedCitation-21993628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21993628 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GRM0-mappedCitation-21993628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21993628 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YVF3-mappedCitation-21993628 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21993628 |