| http://purl.uniprot.org/citations/21993849 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21993849 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21993849 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin 17 receptor E (IL-17RE) is an orphan receptor of the IL-17 receptor family. Here we show that IL-17RE is a receptor specific to IL-17C and has an essential role in host mucosal defense against infection. IL-17C activated downstream signaling through IL-17RE-IL-17RA complex for the induction of genes encoding antibacterial peptides as well as proinflammatory molecules. IL-17C was upregulated in colon epithelial cells during infection with Citrobacter rodentium and acted in synergy with IL-22 to induce the expression of antibacterial peptides in colon epithelial cells. Loss of IL-17C-mediated signaling in IL-17RE-deficient mice led to lower expression of genes encoding antibacterial molecules, greater bacterial burden and early mortality during infection. Together our data identify IL-17RE as a receptor of IL-17C that regulates early innate immunity to intestinal pathogens."xsd:string |
| http://purl.uniprot.org/citations/21993849 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.2155"xsd:string |
| http://purl.uniprot.org/citations/21993849 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.2155"xsd:string |
| http://purl.uniprot.org/citations/21993849 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/21993849 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/21993849 | http://purl.uniprot.org/core/author | "Qian Y."xsd:string |
| http://purl.uniprot.org/citations/21993849 | http://purl.uniprot.org/core/author | "Qian Y."xsd:string |
| http://purl.uniprot.org/citations/21993849 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/21993849 | http://purl.uniprot.org/core/author | "Shi Y."xsd:string |
| http://purl.uniprot.org/citations/21993849 | http://purl.uniprot.org/core/author | "Song X."xsd:string |
| http://purl.uniprot.org/citations/21993849 | http://purl.uniprot.org/core/author | "Song X."xsd:string |
| http://purl.uniprot.org/citations/21993849 | http://purl.uniprot.org/core/author | "Zhu S."xsd:string |
| http://purl.uniprot.org/citations/21993849 | http://purl.uniprot.org/core/author | "Zhu S."xsd:string |
| http://purl.uniprot.org/citations/21993849 | http://purl.uniprot.org/core/author | "Shi P."xsd:string |
| http://purl.uniprot.org/citations/21993849 | http://purl.uniprot.org/core/author | "Shi P."xsd:string |
| http://purl.uniprot.org/citations/21993849 | http://purl.uniprot.org/core/author | "Levin S.D."xsd:string |
| http://purl.uniprot.org/citations/21993849 | http://purl.uniprot.org/core/author | "Levin S.D."xsd:string |
| http://purl.uniprot.org/citations/21993849 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21993849 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21993849 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |
| http://purl.uniprot.org/citations/21993849 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |
| http://purl.uniprot.org/citations/21993849 | http://purl.uniprot.org/core/pages | "1151-1158"xsd:string |
| http://purl.uniprot.org/citations/21993849 | http://purl.uniprot.org/core/pages | "1151-1158"xsd:string |