| http://purl.uniprot.org/citations/21998198 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21998198 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21998198 | http://www.w3.org/2000/01/rdf-schema#comment | "Dysbindin assembles into the biogenesis of lysosome-related organelles complex 1 (BLOC-1), which interacts with the adaptor protein complex 3 (AP-3), mediating a common endosome-trafficking route. Deficiencies in AP-3 and BLOC-1 affect synaptic vesicle composition. However, whether AP-3-BLOC-1-dependent sorting events that control synapse membrane protein content take place in cell bodies upstream of nerve terminals remains unknown. We tested this hypothesis by analyzing the targeting of phosphatidylinositol-4-kinase type II α (PI4KIIα), a membrane protein present in presynaptic and postsynaptic compartments. PI4KIIα copurified with BLOC-1 and AP-3 in neuronal cells. These interactions translated into a decreased PI4KIIα content in the dentate gyrus of dysbindin-null BLOC-1 deficiency and AP-3-null mice. Reduction of PI4KIIα in the dentate reflects a failure to traffic from the cell body. PI4KIIα was targeted to processes in wild-type primary cultured cortical neurons and PC12 cells but failed to reach neurites in cells lacking either AP-3 or BLOC-1. Similarly, disruption of an AP-3-sorting motif in PI4KIIα impaired its sorting into processes of PC12 and primary cultured cortical neuronal cells. Our findings indicate a novel vesicle transport mechanism requiring BLOC-1 and AP-3 complexes for cargo sorting from neuronal cell bodies to neurites and nerve terminals."xsd:string |
| http://purl.uniprot.org/citations/21998198 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e11-07-0592"xsd:string |
| http://purl.uniprot.org/citations/21998198 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e11-07-0592"xsd:string |
| http://purl.uniprot.org/citations/21998198 | http://purl.uniprot.org/core/author | "Faundez V."xsd:string |
| http://purl.uniprot.org/citations/21998198 | http://purl.uniprot.org/core/author | "Faundez V."xsd:string |
| http://purl.uniprot.org/citations/21998198 | http://purl.uniprot.org/core/author | "Smith Y."xsd:string |
| http://purl.uniprot.org/citations/21998198 | http://purl.uniprot.org/core/author | "Smith Y."xsd:string |
| http://purl.uniprot.org/citations/21998198 | http://purl.uniprot.org/core/author | "Talbot K."xsd:string |
| http://purl.uniprot.org/citations/21998198 | http://purl.uniprot.org/core/author | "Talbot K."xsd:string |
| http://purl.uniprot.org/citations/21998198 | http://purl.uniprot.org/core/author | "Craige B."xsd:string |
| http://purl.uniprot.org/citations/21998198 | http://purl.uniprot.org/core/author | "Craige B."xsd:string |
| http://purl.uniprot.org/citations/21998198 | http://purl.uniprot.org/core/author | "Gokhale A."xsd:string |
| http://purl.uniprot.org/citations/21998198 | http://purl.uniprot.org/core/author | "Gokhale A."xsd:string |
| http://purl.uniprot.org/citations/21998198 | http://purl.uniprot.org/core/author | "Larimore J."xsd:string |
| http://purl.uniprot.org/citations/21998198 | http://purl.uniprot.org/core/author | "Larimore J."xsd:string |
| http://purl.uniprot.org/citations/21998198 | http://purl.uniprot.org/core/author | "Lee J.D."xsd:string |
| http://purl.uniprot.org/citations/21998198 | http://purl.uniprot.org/core/author | "Lee J.D."xsd:string |
| http://purl.uniprot.org/citations/21998198 | http://purl.uniprot.org/core/author | "Pare J.F."xsd:string |
| http://purl.uniprot.org/citations/21998198 | http://purl.uniprot.org/core/author | "Pare J.F."xsd:string |
| http://purl.uniprot.org/citations/21998198 | http://purl.uniprot.org/core/author | "Ryder P.V."xsd:string |
| http://purl.uniprot.org/citations/21998198 | http://purl.uniprot.org/core/author | "Ryder P.V."xsd:string |
| http://purl.uniprot.org/citations/21998198 | http://purl.uniprot.org/core/author | "Tornieri K."xsd:string |
| http://purl.uniprot.org/citations/21998198 | http://purl.uniprot.org/core/author | "Tornieri K."xsd:string |