| http://purl.uniprot.org/citations/21998309 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21998309 | http://www.w3.org/2000/01/rdf-schema#comment | "Ca(V)1.3 channels are unique among the high voltage-activated Ca(2+) channel family because they activate at the most negative potentials and display very rapid calcium-dependent inactivation. Both properties are of crucial importance in neurons of the suprachiasmatic nucleus and substantia nigra, where the influx of Ca(2+) ions at subthreshold membrane voltages supports pacemaking function. Previously, alternative splicing in the Ca(V)1.3 C terminus gives rise to a long (Ca(V)1.3(42)) and a short form (Ca(V)1.3(42A)), resulting in a pronounced activation at more negative voltages and faster inactivation in the latter. It was further shown that the C-terminal modulator in the Ca(V)1.3(42) isoforms modulates calmodulin binding to the IQ domain. Using splice variant-specific antibodies, we determined that protein localization of both splice variants in different brain regions were similar. Using the transcript-scanning method, we further identified alternative splicing at four loci in the C terminus of Ca(V)1.3 channels. Alternative splicing of exon 41 removes the IQ motif, resulting in a truncated Ca(V)1.3 protein with diminished inactivation. Splicing of exon 43 causes a frameshift and exhibits a robust inactivation of similar intensity to Ca(V)1.3(42A). Alternative splicing of exons 44 and 48 are in-frame, altering interaction of the distal modulator with the IQ domain and tapering inactivation slightly. Thus, alternative splicing in the C terminus of Ca(V)1.3 channels modulates its electrophysiological properties, which could in turn alter neuronal firing properties and functions."xsd:string |
| http://purl.uniprot.org/citations/21998309 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m111.265207"xsd:string |
| http://purl.uniprot.org/citations/21998309 | http://purl.uniprot.org/core/author | "Huang H."xsd:string |
| http://purl.uniprot.org/citations/21998309 | http://purl.uniprot.org/core/author | "Jiang F."xsd:string |
| http://purl.uniprot.org/citations/21998309 | http://purl.uniprot.org/core/author | "Shen Y."xsd:string |
| http://purl.uniprot.org/citations/21998309 | http://purl.uniprot.org/core/author | "Yu D."xsd:string |
| http://purl.uniprot.org/citations/21998309 | http://purl.uniprot.org/core/author | "Soong T.W."xsd:string |
| http://purl.uniprot.org/citations/21998309 | http://purl.uniprot.org/core/author | "Tan M.Y."xsd:string |
| http://purl.uniprot.org/citations/21998309 | http://purl.uniprot.org/core/author | "Tan B.Z."xsd:string |
| http://purl.uniprot.org/citations/21998309 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21998309 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/21998309 | http://purl.uniprot.org/core/pages | "42725-42735"xsd:string |
| http://purl.uniprot.org/citations/21998309 | http://purl.uniprot.org/core/title | "Functional characterization of alternative splicing in the C terminus of L-type CaV1.3 channels."xsd:string |
| http://purl.uniprot.org/citations/21998309 | http://purl.uniprot.org/core/volume | "286"xsd:string |
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