| http://purl.uniprot.org/citations/22001906 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22001906 | http://www.w3.org/2000/01/rdf-schema#comment | "Although the lung is a defining feature of air-breathing animals, the pathway controlling the formation of type I pneumocytes, the cells that mediate gas exchange, is poorly understood. In contrast, the glucocorticoid receptor and its cognate ligand have long been known to promote type II pneumocyte maturation; prenatal administration of glucocorticoids is commonly used to attenuate the severity of infant respiratory distress syndrome (RDS). Here we show that knock-in mutations of the nuclear co-repressor SMRT (silencing mediator of retinoid and thyroid hormone receptors) in C57BL/6 mice (SMRTmRID) produces a previously unidentified respiratory distress syndrome caused by prematurity of the type I pneumocyte. Though unresponsive to glucocorticoids, treatment with anti-thyroid hormone drugs (propylthiouracil or methimazole) completely rescues SMRT-induced RDS, suggesting an unrecognized and essential role for the thyroid hormone receptor (TR) in lung development. We show that TR and SMRT control type I pneumocyte differentiation through Klf2, which, in turn, seems to directly activate the type I pneumocyte gene program. Conversely, mice without lung Klf2 lack mature type I pneumocytes and die shortly after birth, closely recapitulating the SMRTmRID phenotype. These results identify TR as a second nuclear receptor involved in lung development, specifically type I pneumocyte differentiation, and suggest a possible new type of therapeutic option in the treatment of RDS that is unresponsive to glucocorticoids."xsd:string |
| http://purl.uniprot.org/citations/22001906 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm.2450"xsd:string |
| http://purl.uniprot.org/citations/22001906 | http://purl.uniprot.org/core/author | "Downes M."xsd:string |
| http://purl.uniprot.org/citations/22001906 | http://purl.uniprot.org/core/author | "He M."xsd:string |
| http://purl.uniprot.org/citations/22001906 | http://purl.uniprot.org/core/author | "Leblanc M."xsd:string |
| http://purl.uniprot.org/citations/22001906 | http://purl.uniprot.org/core/author | "Atkins A."xsd:string |
| http://purl.uniprot.org/citations/22001906 | http://purl.uniprot.org/core/author | "Evans R.M."xsd:string |
| http://purl.uniprot.org/citations/22001906 | http://purl.uniprot.org/core/author | "Kawamura K."xsd:string |
| http://purl.uniprot.org/citations/22001906 | http://purl.uniprot.org/core/author | "Yu R.T."xsd:string |
| http://purl.uniprot.org/citations/22001906 | http://purl.uniprot.org/core/author | "Gold D."xsd:string |
| http://purl.uniprot.org/citations/22001906 | http://purl.uniprot.org/core/author | "Lingrel J.B."xsd:string |
| http://purl.uniprot.org/citations/22001906 | http://purl.uniprot.org/core/author | "Pei L."xsd:string |
| http://purl.uniprot.org/citations/22001906 | http://purl.uniprot.org/core/author | "Li H.R."xsd:string |
| http://purl.uniprot.org/citations/22001906 | http://purl.uniprot.org/core/author | "Barish G."xsd:string |
| http://purl.uniprot.org/citations/22001906 | http://purl.uniprot.org/core/author | "Powell H.C."xsd:string |
| http://purl.uniprot.org/citations/22001906 | http://purl.uniprot.org/core/author | "Whyte J."xsd:string |
| http://purl.uniprot.org/citations/22001906 | http://purl.uniprot.org/core/author | "Nofsinger R."xsd:string |
| http://purl.uniprot.org/citations/22001906 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22001906 | http://purl.uniprot.org/core/name | "Nat Med"xsd:string |
| http://purl.uniprot.org/citations/22001906 | http://purl.uniprot.org/core/pages | "1466-1472"xsd:string |
| http://purl.uniprot.org/citations/22001906 | http://purl.uniprot.org/core/title | "Thyroid hormone receptor repression is linked to type I pneumocyte-associated respiratory distress syndrome."xsd:string |
| http://purl.uniprot.org/citations/22001906 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/22001906 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22001906 |
| http://purl.uniprot.org/citations/22001906 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22001906 |