| http://purl.uniprot.org/citations/22006950 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22006950 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22006950 | http://www.w3.org/2000/01/rdf-schema#comment | "Myosin II-driven mechanical forces control epithelial cell shape and morphogenesis. In particular, the circumferential actomyosin belt, which is located along apical cell-cell junctions, regulates many cellular processes. Despite its importance, the molecular mechanisms regulating the belt are not fully understood. In this paper, we characterize Lulu2, a FERM (4.1 protein, ezrin, radixin, moesin) domain-containing molecule homologous to Drosophila melanogaster Yurt, as an important regulator. In epithelial cells, Lulu2 is localized along apical cell-cell boundaries, and Lulu2 depletion by ribonucleic acid interference results in disorganization of the circumferential actomyosin belt. In its regulation of the belt, Lulu2 interacts with and activates p114RhoGEF, a Rho-specific guanine nucleotide exchanging factor (GEF), at apical cell-cell junctions. This interaction is negatively regulated via phosphorylation events in the FERM-adjacent domain of Lulu2 catalyzed by atypical protein kinase C. We further found that Patj, an apical cell polarity regulator, recruits p114RhoGEF to apical cell-cell boundaries via PDZ (PSD-95/Dlg/ZO-1) domain-mediated interaction. These findings therefore reveal a novel molecular system regulating the circumferential actomyosin belt in epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/22006950 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201104118"xsd:string |
| http://purl.uniprot.org/citations/22006950 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201104118"xsd:string |
| http://purl.uniprot.org/citations/22006950 | http://purl.uniprot.org/core/author | "Nakajima H."xsd:string |
| http://purl.uniprot.org/citations/22006950 | http://purl.uniprot.org/core/author | "Nakajima H."xsd:string |
| http://purl.uniprot.org/citations/22006950 | http://purl.uniprot.org/core/author | "Tanoue T."xsd:string |
| http://purl.uniprot.org/citations/22006950 | http://purl.uniprot.org/core/author | "Tanoue T."xsd:string |
| http://purl.uniprot.org/citations/22006950 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22006950 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22006950 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/22006950 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/22006950 | http://purl.uniprot.org/core/pages | "245-261"xsd:string |
| http://purl.uniprot.org/citations/22006950 | http://purl.uniprot.org/core/pages | "245-261"xsd:string |
| http://purl.uniprot.org/citations/22006950 | http://purl.uniprot.org/core/title | "Lulu2 regulates the circumferential actomyosin tensile system in epithelial cells through p114RhoGEF."xsd:string |
| http://purl.uniprot.org/citations/22006950 | http://purl.uniprot.org/core/title | "Lulu2 regulates the circumferential actomyosin tensile system in epithelial cells through p114RhoGEF."xsd:string |
| http://purl.uniprot.org/citations/22006950 | http://purl.uniprot.org/core/volume | "195"xsd:string |
| http://purl.uniprot.org/citations/22006950 | http://purl.uniprot.org/core/volume | "195"xsd:string |
| http://purl.uniprot.org/citations/22006950 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22006950 |
| http://purl.uniprot.org/citations/22006950 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22006950 |
| http://purl.uniprot.org/citations/22006950 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22006950 |
| http://purl.uniprot.org/citations/22006950 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22006950 |
| http://purl.uniprot.org/uniprot/Q6ZSZ5 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/22006950 |
| http://purl.uniprot.org/uniprot/Q9JMC8 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/22006950 |