| http://purl.uniprot.org/citations/22007135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22007135 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22007135 | http://www.w3.org/2000/01/rdf-schema#comment | "Here, we show that a novel Rspo1-Wnt-Vegfc-Vegfr3 signaling pathway plays an essential role in developmental angiogenesis. A mutation in R-spondin1 (rspo1), a Wnt signaling regulator, was uncovered during a forward-genetic screen for angiogenesis-deficient mutants in the zebrafish. Embryos lacking rspo1 or the proposed rspo1 receptor kremen form primary vessels by vasculogenesis, but are defective in subsequent angiogenesis. Endothelial cell-autonomous inhibition of canonical Wnt signaling also blocks angiogenesis in vivo. The pro-angiogenic effects of Rspo1/Wnt signaling are mediated by Vegfc/Vegfr3(Flt4) signaling. Vegfc expression is dependent on Rspo1 and Wnt, and Vegfc and Vegfr3 are necessary to promote angiogenesis downstream from Rspo1-Wnt. As all of these molecules are expressed by the endothelium during sprouting stages, these results suggest that Rspo1-Wnt-VegfC-Vegfr3 signaling plays a crucial role as an endothelial-autonomous permissive cue for developmental angiogenesis."xsd:string |
| http://purl.uniprot.org/citations/22007135 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.068460"xsd:string |
| http://purl.uniprot.org/citations/22007135 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/22007135 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/22007135 | http://purl.uniprot.org/core/author | "Lo B."xsd:string |
| http://purl.uniprot.org/citations/22007135 | http://purl.uniprot.org/core/author | "Lo B."xsd:string |
| http://purl.uniprot.org/citations/22007135 | http://purl.uniprot.org/core/author | "Davis A."xsd:string |
| http://purl.uniprot.org/citations/22007135 | http://purl.uniprot.org/core/author | "Davis A."xsd:string |
| http://purl.uniprot.org/citations/22007135 | http://purl.uniprot.org/core/author | "Swift M.R."xsd:string |
| http://purl.uniprot.org/citations/22007135 | http://purl.uniprot.org/core/author | "Swift M.R."xsd:string |
| http://purl.uniprot.org/citations/22007135 | http://purl.uniprot.org/core/author | "Weinstein B.M."xsd:string |
| http://purl.uniprot.org/citations/22007135 | http://purl.uniprot.org/core/author | "Weinstein B.M."xsd:string |
| http://purl.uniprot.org/citations/22007135 | http://purl.uniprot.org/core/author | "Castranova D."xsd:string |
| http://purl.uniprot.org/citations/22007135 | http://purl.uniprot.org/core/author | "Castranova D."xsd:string |
| http://purl.uniprot.org/citations/22007135 | http://purl.uniprot.org/core/author | "Gore A.V."xsd:string |
| http://purl.uniprot.org/citations/22007135 | http://purl.uniprot.org/core/author | "Gore A.V."xsd:string |
| http://purl.uniprot.org/citations/22007135 | http://purl.uniprot.org/core/author | "Cha Y.R."xsd:string |
| http://purl.uniprot.org/citations/22007135 | http://purl.uniprot.org/core/author | "Cha Y.R."xsd:string |
| http://purl.uniprot.org/citations/22007135 | http://purl.uniprot.org/core/author | "McKinney M.C."xsd:string |
| http://purl.uniprot.org/citations/22007135 | http://purl.uniprot.org/core/author | "McKinney M.C."xsd:string |
| http://purl.uniprot.org/citations/22007135 | http://purl.uniprot.org/core/author | "Mukouyama Y.S."xsd:string |
| http://purl.uniprot.org/citations/22007135 | http://purl.uniprot.org/core/author | "Mukouyama Y.S."xsd:string |
| http://purl.uniprot.org/citations/22007135 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |