| http://purl.uniprot.org/citations/22008548 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22008548 | http://www.w3.org/2000/01/rdf-schema#comment | "Mxi1, a member of the Myc-Max-Mad network, is an antagonist of the c-Myc oncogene and is associated with excessive cell proliferation. Abnormal cell proliferation and tumorigenesis are observed in organs of Mxi1-/-mice. However, the Mxi1-reltaed mechanism of proliferation is unclear. The present study utilized microarray analysis using Mxi1 mouse embryonic fibroblasts (MEFs) to identify genes associated with cell proliferation. Among these genes, insulin-like growth factor binding protein-3 (IGFBP-3) was selected as a candidate gene for real-time PCR to ascertain whether IGFBP-3 expression is regulated by Mxi1. Expression of IGFBP-3 was decreased in Mxi1-/-MEFs and Mxi1-/-mice, and the gene was regulated by Mxi1 in Mxi1 MEFs. Furthermore, proliferation pathways related to IGFBP-3 were regulated in Mxi1-/-mice compared to Mxi1+/+ mice. To determine the effect of Mxi1 inactivation on the induction of cell proliferation, a proliferation assay is performed in both Mxi1 MEFs and Mxi1 mice. Cell viability was regulated by Mxi1 in Mxi1 MEFs and number of PCNA-positive cells was increased in Mxi1-/-mice compared to Mxi1+/+ mice. Moreover, the IGFBP-3 level was decreased in proliferation defect regions in Mxi1-/-mice. The results support the suggestion that inactivation of Mxi1 has a positive effect on cell proliferation by down-regulating IGFBP-3."xsd:string |
| http://purl.uniprot.org/citations/22008548 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2011.10.005"xsd:string |
| http://purl.uniprot.org/citations/22008548 | http://purl.uniprot.org/core/author | "Lee H.W."xsd:string |
| http://purl.uniprot.org/citations/22008548 | http://purl.uniprot.org/core/author | "Park J.H."xsd:string |
| http://purl.uniprot.org/citations/22008548 | http://purl.uniprot.org/core/author | "Yoo K.H."xsd:string |
| http://purl.uniprot.org/citations/22008548 | http://purl.uniprot.org/core/author | "Ko J.Y."xsd:string |
| http://purl.uniprot.org/citations/22008548 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22008548 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/22008548 | http://purl.uniprot.org/core/pages | "36-41"xsd:string |
| http://purl.uniprot.org/citations/22008548 | http://purl.uniprot.org/core/title | "Mxi1 regulates cell proliferation through insulin-like growth factor binding protein-3."xsd:string |
| http://purl.uniprot.org/citations/22008548 | http://purl.uniprot.org/core/volume | "415"xsd:string |
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