| http://purl.uniprot.org/citations/22016516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22016516 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22016516 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcriptional coactivator PGC-1α is a key regulator of cellular energy expenditure in peripheral tissues. Recent studies report that PGC-1α-null mice develop late-onset obesity and that the neuronal inactivation of PGC-1α causes increased food intake. However, the exact role of PGC-1α in the CNS remains unclear. Here we show that PGC-1α directly regulates the expression of the hypothalamic neuropeptide oxytocin, a known central regulator of appetite. We developed a unique genetic approach in the zebrafish, allowing us to monitor and manipulate PGC-1α activity in oxytocinergic neurons. We found that PGC-1α is coexpressed with oxytocin in the zebrafish hypothalamus. Targeted knockdown of the zebrafish PGC-1α gene activity caused a marked decrease in oxytocin mRNA levels and inhibited the expression of a transgenic GFP reporter driven by the oxytocin promoter. The effect of PGC-1α loss of function on oxytocin gene activity was rescued by tissue-specific re-expression of either PGC-1α or oxytocin precursor in zebrafish oxytocinergic neurons. PGC-1α activated the oxytocin promoter in a heterologous cell culture system, and overexpression of PGC-1α induced ectopic expression of oxytocin in muscles and neurons. Finally, PGC-1α forms an in vivo complex with the oxytocin promoter in fed but not fasted animals. These findings demonstrate that PGC-1α is both necessary and sufficient for the production of oxytocin, implicating hypothalamic PGC-1α in the direct activation of a hypothalamic hormone known to control energy intake."xsd:string |
| http://purl.uniprot.org/citations/22016516 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.1798-11.2011"xsd:string |
| http://purl.uniprot.org/citations/22016516 | http://purl.uniprot.org/core/author | "Ben-Dor S."xsd:string |
| http://purl.uniprot.org/citations/22016516 | http://purl.uniprot.org/core/author | "Ben-Dor S."xsd:string |
| http://purl.uniprot.org/citations/22016516 | http://purl.uniprot.org/core/author | "Blechman J."xsd:string |
| http://purl.uniprot.org/citations/22016516 | http://purl.uniprot.org/core/author | "Blechman J."xsd:string |
| http://purl.uniprot.org/citations/22016516 | http://purl.uniprot.org/core/author | "Levkowitz G."xsd:string |
| http://purl.uniprot.org/citations/22016516 | http://purl.uniprot.org/core/author | "Levkowitz G."xsd:string |
| http://purl.uniprot.org/citations/22016516 | http://purl.uniprot.org/core/author | "Amir-Zilberstein L."xsd:string |
| http://purl.uniprot.org/citations/22016516 | http://purl.uniprot.org/core/author | "Amir-Zilberstein L."xsd:string |
| http://purl.uniprot.org/citations/22016516 | http://purl.uniprot.org/core/author | "Gutnick A."xsd:string |
| http://purl.uniprot.org/citations/22016516 | http://purl.uniprot.org/core/author | "Gutnick A."xsd:string |
| http://purl.uniprot.org/citations/22016516 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22016516 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22016516 | http://purl.uniprot.org/core/name | "J. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/22016516 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/22016516 | http://purl.uniprot.org/core/pages | "14835-14840"xsd:string |
| http://purl.uniprot.org/citations/22016516 | http://purl.uniprot.org/core/pages | "14835-14840"xsd:string |
| http://purl.uniprot.org/citations/22016516 | http://purl.uniprot.org/core/title | "The metabolic regulator PGC-1alpha directly controls the expression of the hypothalamic neuropeptide oxytocin."xsd:string |
| http://purl.uniprot.org/citations/22016516 | http://purl.uniprot.org/core/title | "The metabolic regulator PGC-1alpha directly controls the expression of the hypothalamic neuropeptide oxytocin."xsd:string |
| http://purl.uniprot.org/citations/22016516 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/22016516 | http://purl.uniprot.org/core/volume | "31"xsd:string |
| http://purl.uniprot.org/citations/22016516 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22016516 |