| http://purl.uniprot.org/citations/22017988 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22017988 | http://www.w3.org/2000/01/rdf-schema#comment | "Video abstractDuring development, dendrites arborize in a field several hundred folds of their soma size, a process regulated by intrinsic transcription program and cell adhesion molecule (CAM)-mediated interaction. However, underlying cellular machineries that govern distal higher-order dendrite extension remain largely unknown. Here, we show that Nak, a clathrin adaptor-associated kinase, promotes higher-order dendrite growth through endocytosis. In nak mutants, both the number and length of higher-order dendrites are reduced, which are phenocopied by disruptions of clathrin-mediated endocytosis. Nak interacts genetically with components of the endocytic pathway, colocalizes with clathrin puncta, and is required for dendritic localization of clathrin puncta. More importantly, these Nak-containing clathrin structures preferentially localize to branching points and dendritic tips that are undergoing active growth. We present evidence that the Drosophila L1-CAM homolog Neuroglian is a relevant cargo of Nak-dependent internalization, suggesting that localized clathrin-mediated endocytosis of CAMs facilitates the extension of nearby higher-order dendrites."xsd:string |
| http://purl.uniprot.org/citations/22017988 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2011.08.028"xsd:string |
| http://purl.uniprot.org/citations/22017988 | http://purl.uniprot.org/core/author | "Chang H.C."xsd:string |
| http://purl.uniprot.org/citations/22017988 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/22017988 | http://purl.uniprot.org/core/author | "Lin Y.C."xsd:string |
| http://purl.uniprot.org/citations/22017988 | http://purl.uniprot.org/core/author | "Zhou X."xsd:string |
| http://purl.uniprot.org/citations/22017988 | http://purl.uniprot.org/core/author | "Peng Y.H."xsd:string |
| http://purl.uniprot.org/citations/22017988 | http://purl.uniprot.org/core/author | "Ou C.Y."xsd:string |
| http://purl.uniprot.org/citations/22017988 | http://purl.uniprot.org/core/author | "Wang C.H."xsd:string |
| http://purl.uniprot.org/citations/22017988 | http://purl.uniprot.org/core/author | "Lin H.C."xsd:string |
| http://purl.uniprot.org/citations/22017988 | http://purl.uniprot.org/core/author | "Chien C.T."xsd:string |
| http://purl.uniprot.org/citations/22017988 | http://purl.uniprot.org/core/author | "Lin W.H."xsd:string |
| http://purl.uniprot.org/citations/22017988 | http://purl.uniprot.org/core/author | "Pi H."xsd:string |
| http://purl.uniprot.org/citations/22017988 | http://purl.uniprot.org/core/author | "Yang W.K."xsd:string |
| http://purl.uniprot.org/citations/22017988 | http://purl.uniprot.org/core/author | "Lai T.T."xsd:string |
| http://purl.uniprot.org/citations/22017988 | http://purl.uniprot.org/core/author | "Suo H."xsd:string |
| http://purl.uniprot.org/citations/22017988 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22017988 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/22017988 | http://purl.uniprot.org/core/pages | "285-299"xsd:string |
| http://purl.uniprot.org/citations/22017988 | http://purl.uniprot.org/core/title | "Nak regulates localization of clathrin sites in higher-order dendrites to promote local dendrite growth."xsd:string |
| http://purl.uniprot.org/citations/22017988 | http://purl.uniprot.org/core/volume | "72"xsd:string |
| http://purl.uniprot.org/citations/22017988 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22017988 |
| http://purl.uniprot.org/citations/22017988 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22017988 |
| http://purl.uniprot.org/uniprot/Q9VJ30#attribution-3804C908335438D274D0A654965310CA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22017988 |