| http://purl.uniprot.org/citations/22018494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22018494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22018494 | http://www.w3.org/2000/01/rdf-schema#comment | "Conserved DNA-damage responses (DDRs) efficiently cope with replication blocks and double-strand breaks (DSBs) in cultured eukaryotic cells; DDRs in tissues remain poorly understood. DDR-inactivating mutations lethal in animals are tolerated in Arabidopsis, whose root meristem provides a powerful stem-cell-niche model. We imaged UVB-induced death of specific meristem cells in single and double Arabidopsis mutants to elucidate cooperation among DNA translesion synthesis (TLS) polymerases (Polη, Polζ) and DNA-damage-activated protein kinases (ATR, ATM). Death was 100-fold higher in stem and progenitor (StPr) cells than in transiently amplifying cells. Quantitative analyses of dose-response plots showed that Polη and Polζ act redundantly to tolerate replication blocks and that Polζ-mediated TLS requires ATR. Deficient TLS resulted in ATM-signaled death, which first appeared 10-14h post-UVB. Although ssDNA downstream of blocks was likely cleaved into DSBs throughout S phase, death pathways appeared to initiate late in S. In atm mutants death appeared much later, likely signaled by a slow ATR-dependent pathway. To bypass replication blocks, tissues may use TLS rather than error-free pathways that could generate genomic aberrations. Dynamic balances among ATR and ATM death-avoidance and death-signaling functions determine how many DSB-burdened StPr cells are killed. Their replacement by less-burdened quiescent-center cells then restores growth homeostasis."xsd:string |
| http://purl.uniprot.org/citations/22018494 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.dnarep.2011.10.001"xsd:string |
| http://purl.uniprot.org/citations/22018494 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.dnarep.2011.10.001"xsd:string |
| http://purl.uniprot.org/citations/22018494 | http://purl.uniprot.org/core/author | "Hays J.B."xsd:string |
| http://purl.uniprot.org/citations/22018494 | http://purl.uniprot.org/core/author | "Hays J.B."xsd:string |
| http://purl.uniprot.org/citations/22018494 | http://purl.uniprot.org/core/author | "Curtis M.J."xsd:string |
| http://purl.uniprot.org/citations/22018494 | http://purl.uniprot.org/core/author | "Curtis M.J."xsd:string |
| http://purl.uniprot.org/citations/22018494 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22018494 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22018494 | http://purl.uniprot.org/core/name | "DNA Repair"xsd:string |
| http://purl.uniprot.org/citations/22018494 | http://purl.uniprot.org/core/name | "DNA Repair"xsd:string |
| http://purl.uniprot.org/citations/22018494 | http://purl.uniprot.org/core/pages | "1272-1281"xsd:string |
| http://purl.uniprot.org/citations/22018494 | http://purl.uniprot.org/core/pages | "1272-1281"xsd:string |
| http://purl.uniprot.org/citations/22018494 | http://purl.uniprot.org/core/title | "Cooperative responses of DNA-damage-activated protein kinases ATR and ATM and DNA translesion polymerases to replication-blocking DNA damage in a stem-cell niche."xsd:string |
| http://purl.uniprot.org/citations/22018494 | http://purl.uniprot.org/core/title | "Cooperative responses of DNA-damage-activated protein kinases ATR and ATM and DNA translesion polymerases to replication-blocking DNA damage in a stem-cell niche."xsd:string |
| http://purl.uniprot.org/citations/22018494 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/22018494 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/22018494 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22018494 |
| http://purl.uniprot.org/citations/22018494 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22018494 |
| http://purl.uniprot.org/citations/22018494 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22018494 |
| http://purl.uniprot.org/citations/22018494 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22018494 |
| http://purl.uniprot.org/uniprot/Q8H2D5 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/22018494 |
| http://purl.uniprot.org/uniprot/Q8H2D5#attribution-A73AF1C6460505D8E1BFAF55B3C9EC72 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22018494 |