| http://purl.uniprot.org/citations/22022271 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22022271 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22022271 | http://www.w3.org/2000/01/rdf-schema#comment | "Barrier epithelia that are persistently exposed to microbes have evolved potent immune tools to eliminate such pathogens. If mechanisms that control Drosophila systemic responses are well-characterized, the epithelial immune responses remain poorly understood. Here, we performed a genetic dissection of the cascades activated during the immune response of the Drosophila airway epithelium i.e. trachea. We present evidence that bacteria induced-antimicrobial peptide (AMP) production in the trachea is controlled by two signalling cascades. AMP gene transcription is activated by the inducible IMD pathway that acts non-cell autonomously in trachea. This IMD-dependent AMP activation is antagonized by a constitutively active signalling module involving the receptor Toll-8/Tollo, the ligand Spätzle2/DNT1 and Ect-4, the Drosophila ortholog of the human Sterile alpha and HEAT/ARMadillo motif (SARM). Our data show that, in addition to Toll-1 whose function is essential during the systemic immune response, Drosophila relies on another Toll family member to control the immune response in the respiratory epithelium."xsd:string |
| http://purl.uniprot.org/citations/22022271 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.ppat.1002319"xsd:string |
| http://purl.uniprot.org/citations/22022271 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.ppat.1002319"xsd:string |
| http://purl.uniprot.org/citations/22022271 | http://purl.uniprot.org/core/author | "Charroux B."xsd:string |
| http://purl.uniprot.org/citations/22022271 | http://purl.uniprot.org/core/author | "Charroux B."xsd:string |
| http://purl.uniprot.org/citations/22022271 | http://purl.uniprot.org/core/author | "Akhouayri I."xsd:string |
| http://purl.uniprot.org/citations/22022271 | http://purl.uniprot.org/core/author | "Akhouayri I."xsd:string |
| http://purl.uniprot.org/citations/22022271 | http://purl.uniprot.org/core/author | "Royet J."xsd:string |
| http://purl.uniprot.org/citations/22022271 | http://purl.uniprot.org/core/author | "Royet J."xsd:string |
| http://purl.uniprot.org/citations/22022271 | http://purl.uniprot.org/core/author | "Turc C."xsd:string |
| http://purl.uniprot.org/citations/22022271 | http://purl.uniprot.org/core/author | "Turc C."xsd:string |
| http://purl.uniprot.org/citations/22022271 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22022271 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22022271 | http://purl.uniprot.org/core/name | "PLoS Pathog."xsd:string |
| http://purl.uniprot.org/citations/22022271 | http://purl.uniprot.org/core/name | "PLoS Pathog."xsd:string |
| http://purl.uniprot.org/citations/22022271 | http://purl.uniprot.org/core/pages | "E1002319"xsd:string |
| http://purl.uniprot.org/citations/22022271 | http://purl.uniprot.org/core/pages | "E1002319"xsd:string |
| http://purl.uniprot.org/citations/22022271 | http://purl.uniprot.org/core/title | "Toll-8/Tollo negatively regulates antimicrobial response in the Drosophila respiratory epithelium."xsd:string |
| http://purl.uniprot.org/citations/22022271 | http://purl.uniprot.org/core/title | "Toll-8/Tollo negatively regulates antimicrobial response in the Drosophila respiratory epithelium."xsd:string |
| http://purl.uniprot.org/citations/22022271 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/22022271 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/22022271 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22022271 |
| http://purl.uniprot.org/citations/22022271 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22022271 |