| http://purl.uniprot.org/citations/22022577 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22022577 | http://www.w3.org/2000/01/rdf-schema#comment | "Retinoic acid (RA) has been approved for the differentiation therapy of neuroblastoma (NB). Previous work revealed a correlation between glucose-regulated protein 75 (GRP75) and the RA-elicited neuronal differentiation of NB cells. The present study further demonstrated that GRP75 translocates into the nucleus and physically interacts with retinoid receptors (RARα and RXRα) to augment RA-elicited neuronal differentiation. GRP75 was required for RARα/RXRα-mediated transcriptional regulation and was shown to reduce the proteasome-mediated degradation of RARα/RXRαin a RA-dependent manner. More intriguingly, the level of GRP75/RARα/RXRα tripartite complexes was tightly associated with the RA-induced suppression of tumor growth in animals and the histological grade of differentiation in human NB tumors. The formation of GRP75/RARα/RXRα complexes was intimately correlated with a normal MYCN copy number of NB tumors, possibly implicating a favorable prognosis of NB tumors. The present findings reveal a novel function of nucleus-localized GRP75 in actively promoting neuronal differentiation, delineating the mode of action for the differentiation therapy of NB by RA."xsd:string |
| http://purl.uniprot.org/citations/22022577 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0026236"xsd:string |
| http://purl.uniprot.org/citations/22022577 | http://purl.uniprot.org/core/author | "Lee H."xsd:string |
| http://purl.uniprot.org/citations/22022577 | http://purl.uniprot.org/core/author | "Nakagawara A."xsd:string |
| http://purl.uniprot.org/citations/22022577 | http://purl.uniprot.org/core/author | "Lin D.T."xsd:string |
| http://purl.uniprot.org/citations/22022577 | http://purl.uniprot.org/core/author | "Pan C.Y."xsd:string |
| http://purl.uniprot.org/citations/22022577 | http://purl.uniprot.org/core/author | "Tsay Y.G."xsd:string |
| http://purl.uniprot.org/citations/22022577 | http://purl.uniprot.org/core/author | "Juan H.F."xsd:string |
| http://purl.uniprot.org/citations/22022577 | http://purl.uniprot.org/core/author | "Hsieh F.J."xsd:string |
| http://purl.uniprot.org/citations/22022577 | http://purl.uniprot.org/core/author | "Liao Y.F."xsd:string |
| http://purl.uniprot.org/citations/22022577 | http://purl.uniprot.org/core/author | "Shih Y.Y."xsd:string |
| http://purl.uniprot.org/citations/22022577 | http://purl.uniprot.org/core/author | "Hsu W.M."xsd:string |
| http://purl.uniprot.org/citations/22022577 | http://purl.uniprot.org/core/author | "Jeng Y.M."xsd:string |
| http://purl.uniprot.org/citations/22022577 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22022577 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/22022577 | http://purl.uniprot.org/core/pages | "e26236"xsd:string |
| http://purl.uniprot.org/citations/22022577 | http://purl.uniprot.org/core/title | "Nuclear GRP75 binds retinoic acid receptors to promote neuronal differentiation of neuroblastoma."xsd:string |
| http://purl.uniprot.org/citations/22022577 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/22022577 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22022577 |
| http://purl.uniprot.org/citations/22022577 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22022577 |
| http://purl.uniprot.org/uniprot/#_A0A5F9ZHH6-mappedCitation-22022577 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22022577 |
| http://purl.uniprot.org/uniprot/#_A1XP52-mappedCitation-22022577 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22022577 |
| http://purl.uniprot.org/uniprot/#_A0A384P5G6-mappedCitation-22022577 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22022577 |
| http://purl.uniprot.org/uniprot/#_B7Z1V7-mappedCitation-22022577 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22022577 |