| http://purl.uniprot.org/citations/22024014 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22024014 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22024014 | http://www.w3.org/2000/01/rdf-schema#comment | "Kunitz-type protease inhibitors, which consist of around 60 amino acid residues and three distinctive disulfide bridges, exhibit a broad range of physiological functions such as protease inhibitor and ion channel blocker. In this study, we identified cDNAs encoding Kunitz-type protease inhibitors, Pr-mulgins 1, 2 and 3, from the venom gland cDNA library of Papuan pigmy mulga snake (New Guinean Pseudechis australis). The deduced amino acid sequences of the Pr-mulgins are 92.4-99.3% identical with their orthologs in Australian P. australis. Pr-mulgin proteins were recombinantly prepared and subjected to inhibitory assays against proteases. Pr-mulgin 1 significantly affected matrix metalloprotease (MMP) 2; Pr-mulgins 2 and 3 showed potent inhibition to trypsin and plasma plasmin; and Pr-mulgin 2 inhibited α-chymotrypsin. Pr-mulgins 1, 2, and 3, however, had essentially no effect on Drosophila K(+) channels (Shaker) and rat K(+) channels (K(v) 1.1)."xsd:string |
| http://purl.uniprot.org/citations/22024014 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.toxicon.2011.10.005"xsd:string |
| http://purl.uniprot.org/citations/22024014 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.toxicon.2011.10.005"xsd:string |
| http://purl.uniprot.org/citations/22024014 | http://purl.uniprot.org/core/author | "Inagaki H."xsd:string |
| http://purl.uniprot.org/citations/22024014 | http://purl.uniprot.org/core/author | "Inagaki H."xsd:string |
| http://purl.uniprot.org/citations/22024014 | http://purl.uniprot.org/core/author | "Kimoto H."xsd:string |
| http://purl.uniprot.org/citations/22024014 | http://purl.uniprot.org/core/author | "Kimoto H."xsd:string |
| http://purl.uniprot.org/citations/22024014 | http://purl.uniprot.org/core/author | "Kubo T."xsd:string |
| http://purl.uniprot.org/citations/22024014 | http://purl.uniprot.org/core/author | "Kubo T."xsd:string |
| http://purl.uniprot.org/citations/22024014 | http://purl.uniprot.org/core/author | "Yamauchi Y."xsd:string |
| http://purl.uniprot.org/citations/22024014 | http://purl.uniprot.org/core/author | "Yamauchi Y."xsd:string |
| http://purl.uniprot.org/citations/22024014 | http://purl.uniprot.org/core/author | "Toriba M."xsd:string |
| http://purl.uniprot.org/citations/22024014 | http://purl.uniprot.org/core/author | "Toriba M."xsd:string |
| http://purl.uniprot.org/citations/22024014 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22024014 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22024014 | http://purl.uniprot.org/core/name | "Toxicon"xsd:string |
| http://purl.uniprot.org/citations/22024014 | http://purl.uniprot.org/core/name | "Toxicon"xsd:string |
| http://purl.uniprot.org/citations/22024014 | http://purl.uniprot.org/core/pages | "74-80"xsd:string |
| http://purl.uniprot.org/citations/22024014 | http://purl.uniprot.org/core/pages | "74-80"xsd:string |
| http://purl.uniprot.org/citations/22024014 | http://purl.uniprot.org/core/title | "Functional characterization of Kunitz-type protease inhibitor Pr-mulgins identified from New Guinean Pseudechis australis."xsd:string |
| http://purl.uniprot.org/citations/22024014 | http://purl.uniprot.org/core/title | "Functional characterization of Kunitz-type protease inhibitor Pr-mulgins identified from New Guinean Pseudechis australis."xsd:string |
| http://purl.uniprot.org/citations/22024014 | http://purl.uniprot.org/core/volume | "59"xsd:string |
| http://purl.uniprot.org/citations/22024014 | http://purl.uniprot.org/core/volume | "59"xsd:string |