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http://purl.uniprot.org/citations/22024395 | http://www.w3.org/2000/01/rdf-schema#comment | "Fanconi anemia (FA) and Bloom's syndrome (BS) are rare hereditary chromosomal instability disorders. FA displays bone marrow failure, acute myeloid leukemia, and head and neck cancers, whereas BS is characterized by growth retardation, immunodeficiency, and a wide spectrum of cancers. The BLM gene mutated in BS encodes a DNA helicase that functions in a protein complex to suppress sister-chromatid exchange. Of the 15 FA genetic complementation groups implicated in interstrand crosslink repair, FANCJ encodes a DNA helicase involved in recombinational repair and replication stress response. Based on evidence that BLM and FANCJ interact we suggest that crosstalk between BLM and FA pathways is more complex than previously thought. We propose testable models for how FANCJ and BLM coordinate to help cells deal with stalled replication forks or double-strand breaks (DSB). Understanding how BLM and FANCJ cooperate will help to elucidate an important pathway for maintaining genomic stability."xsd:string |
http://purl.uniprot.org/citations/22024395 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.tig.2011.09.003"xsd:string |
http://purl.uniprot.org/citations/22024395 | http://purl.uniprot.org/core/author | "Brosh R.M. Jr."xsd:string |
http://purl.uniprot.org/citations/22024395 | http://purl.uniprot.org/core/author | "Suhasini A.N."xsd:string |
http://purl.uniprot.org/citations/22024395 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
http://purl.uniprot.org/citations/22024395 | http://purl.uniprot.org/core/name | "Trends Genet"xsd:string |
http://purl.uniprot.org/citations/22024395 | http://purl.uniprot.org/core/pages | "7-13"xsd:string |
http://purl.uniprot.org/citations/22024395 | http://purl.uniprot.org/core/title | "Fanconi anemia and Bloom's syndrome crosstalk through FANCJ-BLM helicase interaction."xsd:string |
http://purl.uniprot.org/citations/22024395 | http://purl.uniprot.org/core/volume | "28"xsd:string |
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