http://purl.uniprot.org/citations/22024480 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/22024480 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously reported that IκBL prevents experimental autoimmune arthritis. The molecular mechanism, however, still remains unclear. In contrast to four splicing-isoforms of IκBL in human, two isoforms were identified in mouse. The major isoform IκBL-α(S) suppressed LPS-induced NF-κB activation and transcription of TNFα and IL-6, but not IL-1β. The suppressive activity required the nuclear localization signal and the ankyrin repeat domain of IκBL. IκBL did not affect the nuclear translocation of the NF-κB dimer. These findings point to IκBL as being a novel member of the nuclear IκB family, which functions in the nucleus and controls various inflammatory responses including autoimmune arthritis."xsd:string |
http://purl.uniprot.org/citations/22024480 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2011.10.024"xsd:string |
http://purl.uniprot.org/citations/22024480 | http://purl.uniprot.org/core/author | "Kimura M."xsd:string |
http://purl.uniprot.org/citations/22024480 | http://purl.uniprot.org/core/author | "Inoko H."xsd:string |
http://purl.uniprot.org/citations/22024480 | http://purl.uniprot.org/core/author | "Sato T."xsd:string |
http://purl.uniprot.org/citations/22024480 | http://purl.uniprot.org/core/author | "Miyashita K."xsd:string |
http://purl.uniprot.org/citations/22024480 | http://purl.uniprot.org/core/author | "Chiba T."xsd:string |
http://purl.uniprot.org/citations/22024480 | http://purl.uniprot.org/core/author | "Warita T."xsd:string |
http://purl.uniprot.org/citations/22024480 | http://purl.uniprot.org/core/author | "Sugoh T."xsd:string |
http://purl.uniprot.org/citations/22024480 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
http://purl.uniprot.org/citations/22024480 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
http://purl.uniprot.org/citations/22024480 | http://purl.uniprot.org/core/pages | "3577-3581"xsd:string |
http://purl.uniprot.org/citations/22024480 | http://purl.uniprot.org/core/title | "IkappaBL, a novel member of the nuclear IkappaB family, inhibits inflammatory cytokine expression."xsd:string |
http://purl.uniprot.org/citations/22024480 | http://purl.uniprot.org/core/volume | "585"xsd:string |
http://purl.uniprot.org/citations/22024480 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22024480 |
http://purl.uniprot.org/citations/22024480 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22024480 |
http://purl.uniprot.org/uniprot/O88995#attribution-0619876B28E995625E9B8F50A95D33C5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22024480 |
http://purl.uniprot.org/uniprot/#_Q3V006-mappedCitation-22024480 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22024480 |
http://purl.uniprot.org/uniprot/#_O88995-mappedCitation-22024480 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22024480 |
http://purl.uniprot.org/uniprot/Q3V006 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22024480 |
http://purl.uniprot.org/uniprot/O88995 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22024480 |