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http://purl.uniprot.org/citations/22024480http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22024480http://www.w3.org/2000/01/rdf-schema#comment"We previously reported that IκBL prevents experimental autoimmune arthritis. The molecular mechanism, however, still remains unclear. In contrast to four splicing-isoforms of IκBL in human, two isoforms were identified in mouse. The major isoform IκBL-α(S) suppressed LPS-induced NF-κB activation and transcription of TNFα and IL-6, but not IL-1β. The suppressive activity required the nuclear localization signal and the ankyrin repeat domain of IκBL. IκBL did not affect the nuclear translocation of the NF-κB dimer. These findings point to IκBL as being a novel member of the nuclear IκB family, which functions in the nucleus and controls various inflammatory responses including autoimmune arthritis."xsd:string
http://purl.uniprot.org/citations/22024480http://purl.org/dc/terms/identifier"doi:10.1016/j.febslet.2011.10.024"xsd:string
http://purl.uniprot.org/citations/22024480http://purl.uniprot.org/core/author"Kimura M."xsd:string
http://purl.uniprot.org/citations/22024480http://purl.uniprot.org/core/author"Inoko H."xsd:string
http://purl.uniprot.org/citations/22024480http://purl.uniprot.org/core/author"Sato T."xsd:string
http://purl.uniprot.org/citations/22024480http://purl.uniprot.org/core/author"Miyashita K."xsd:string
http://purl.uniprot.org/citations/22024480http://purl.uniprot.org/core/author"Chiba T."xsd:string
http://purl.uniprot.org/citations/22024480http://purl.uniprot.org/core/author"Warita T."xsd:string
http://purl.uniprot.org/citations/22024480http://purl.uniprot.org/core/author"Sugoh T."xsd:string
http://purl.uniprot.org/citations/22024480http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/22024480http://purl.uniprot.org/core/name"FEBS Lett"xsd:string
http://purl.uniprot.org/citations/22024480http://purl.uniprot.org/core/pages"3577-3581"xsd:string
http://purl.uniprot.org/citations/22024480http://purl.uniprot.org/core/title"IkappaBL, a novel member of the nuclear IkappaB family, inhibits inflammatory cytokine expression."xsd:string
http://purl.uniprot.org/citations/22024480http://purl.uniprot.org/core/volume"585"xsd:string
http://purl.uniprot.org/citations/22024480http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/22024480
http://purl.uniprot.org/citations/22024480http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/22024480
http://purl.uniprot.org/uniprot/O88995#attribution-0619876B28E995625E9B8F50A95D33C5http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/22024480
http://purl.uniprot.org/uniprot/#_Q3V006-mappedCitation-22024480http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22024480
http://purl.uniprot.org/uniprot/#_O88995-mappedCitation-22024480http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22024480
http://purl.uniprot.org/uniprot/Q3V006http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/22024480
http://purl.uniprot.org/uniprot/O88995http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/22024480