| http://purl.uniprot.org/citations/22025562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22025562 | http://www.w3.org/2000/01/rdf-schema#comment | "Downregulation of the proapoptotic p53 target gene glioma pathogenesis-related protein 1 (GLIPR1) occurs frequently in prostate cancer, but the functional meaning of this event is obscure. Here, we report the discovery of functional relationship between GLIPR1 and c-Myc in prostate cancer where c-Myc is often upregulated. We found that the expression of GLIPR1 and c-Myc were inversely correlated in human prostate cancer. Restoration of GLIPR1 expression in prostate cancer cells downregulated c-myc levels, inhibiting cell-cycle progression. Downregulation was linked to a reduction in β-catenin/TCF4-mediated transcription of the c-myc gene, which was caused by GLIPR1-mediated redistribution of casein kinase 1α (CK1α) from the Golgi apparatus to the cytoplasm where CK1α could phosphorylate β-catenin and mediate its destruction. In parallel, GLIPR1 also promoted c-Myc protein ubiquitination and degradation by glycogen synthase kinase-3α-and/or CK1α-mediated c-Myc phosphorylation. Notably, genetic ablation of the mouse homolog of Glipr1 cooperated with c-myc overexpression to induce prostatic intraepithelial neoplasia and prostate cancer. Together, our findings provide evidence for CK1α-mediated destruction of c-Myc and identify c-Myc S252 as a crucial CK1α phosphorylation site for c-Myc degradation. Furthermore, they reveal parallel mechanisms of c-myc downregulation by GLIPR1 that when ablated in the prostate are sufficient to drive c-Myc expression and malignant development."xsd:string |
| http://purl.uniprot.org/citations/22025562 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-11-1714"xsd:string |
| http://purl.uniprot.org/citations/22025562 | http://purl.uniprot.org/core/author | "Kim S.M."xsd:string |
| http://purl.uniprot.org/citations/22025562 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/22025562 | http://purl.uniprot.org/core/author | "Lee J.S."xsd:string |
| http://purl.uniprot.org/citations/22025562 | http://purl.uniprot.org/core/author | "Park S."xsd:string |
| http://purl.uniprot.org/citations/22025562 | http://purl.uniprot.org/core/author | "Yang G."xsd:string |
| http://purl.uniprot.org/citations/22025562 | http://purl.uniprot.org/core/author | "Ren C."xsd:string |
| http://purl.uniprot.org/citations/22025562 | http://purl.uniprot.org/core/author | "Ittmann M.M."xsd:string |
| http://purl.uniprot.org/citations/22025562 | http://purl.uniprot.org/core/author | "Goltsov A.A."xsd:string |
| http://purl.uniprot.org/citations/22025562 | http://purl.uniprot.org/core/author | "Thompson T.C."xsd:string |
| http://purl.uniprot.org/citations/22025562 | http://purl.uniprot.org/core/author | "Demayo F.J."xsd:string |
| http://purl.uniprot.org/citations/22025562 | http://purl.uniprot.org/core/author | "Troncoso P."xsd:string |
| http://purl.uniprot.org/citations/22025562 | http://purl.uniprot.org/core/author | "Fattah E.A."xsd:string |
| http://purl.uniprot.org/citations/22025562 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22025562 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/22025562 | http://purl.uniprot.org/core/pages | "7694-7704"xsd:string |
| http://purl.uniprot.org/citations/22025562 | http://purl.uniprot.org/core/title | "GLIPR1 suppresses prostate cancer development through targeted oncoprotein destruction."xsd:string |
| http://purl.uniprot.org/citations/22025562 | http://purl.uniprot.org/core/volume | "71"xsd:string |
| http://purl.uniprot.org/citations/22025562 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22025562 |
| http://purl.uniprot.org/citations/22025562 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22025562 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1R1-mappedCitation-22025562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22025562 |
| http://purl.uniprot.org/uniprot/#_A0N2G3-mappedCitation-22025562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22025562 |
| http://purl.uniprot.org/uniprot/#_A0A224B085-mappedCitation-22025562 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22025562 |