| http://purl.uniprot.org/citations/22025725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22025725 | http://www.w3.org/2000/01/rdf-schema#comment | "Bipolar disorder is a debilitating psychopathology with unknown etiology. Accumulating evidence suggests the possible involvement of Na(+),K(+)-ATPase dysfunction in the pathophysiology of bipolar disorder. Here we show that Myshkin mice carrying an inactivating mutation in the neuron-specific Na(+),K(+)-ATPase α3 subunit display a behavioral profile remarkably similar to bipolar patients in the manic state. Myshkin mice show increased Ca(2+) signaling in cultured cortical neurons and phospho-activation of extracellular signal regulated kinase (ERK) and Akt in the hippocampus. The mood-stabilizing drugs lithium and valproic acid, specific ERK inhibitor SL327, rostafuroxin, and transgenic expression of a functional Na(+),K(+)-ATPase α3 protein rescue the mania-like phenotype of Myshkin mice. These findings establish Myshkin mice as a unique model of mania, reveal an important role for Na(+),K(+)-ATPase α3 in the control of mania-like behavior, and identify Na(+),K(+)-ATPase α3, its physiological regulators and downstream signal transduction pathways as putative targets for the design of new antimanic therapies."xsd:string |
| http://purl.uniprot.org/citations/22025725 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1108416108"xsd:string |
| http://purl.uniprot.org/citations/22025725 | http://purl.uniprot.org/core/author | "Duffy S."xsd:string |
| http://purl.uniprot.org/citations/22025725 | http://purl.uniprot.org/core/author | "Petersen J."xsd:string |
| http://purl.uniprot.org/citations/22025725 | http://purl.uniprot.org/core/author | "Vilsen B."xsd:string |
| http://purl.uniprot.org/citations/22025725 | http://purl.uniprot.org/core/author | "Roder J.C."xsd:string |
| http://purl.uniprot.org/citations/22025725 | http://purl.uniprot.org/core/author | "Clapcote S.J."xsd:string |
| http://purl.uniprot.org/citations/22025725 | http://purl.uniprot.org/core/author | "Cortez M.A."xsd:string |
| http://purl.uniprot.org/citations/22025725 | http://purl.uniprot.org/core/author | "Ralph M.R."xsd:string |
| http://purl.uniprot.org/citations/22025725 | http://purl.uniprot.org/core/author | "Snead O.C."xsd:string |
| http://purl.uniprot.org/citations/22025725 | http://purl.uniprot.org/core/author | "Kirshenbaum G.S."xsd:string |
| http://purl.uniprot.org/citations/22025725 | http://purl.uniprot.org/core/author | "Peever J.H."xsd:string |
| http://purl.uniprot.org/citations/22025725 | http://purl.uniprot.org/core/author | "Burgess C.R."xsd:string |
| http://purl.uniprot.org/citations/22025725 | http://purl.uniprot.org/core/author | "Jarowek K.J."xsd:string |
| http://purl.uniprot.org/citations/22025725 | http://purl.uniprot.org/core/author | "Yucel Y.H."xsd:string |
| http://purl.uniprot.org/citations/22025725 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22025725 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/22025725 | http://purl.uniprot.org/core/pages | "18144-18149"xsd:string |
| http://purl.uniprot.org/citations/22025725 | http://purl.uniprot.org/core/title | "Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase alpha3 sodium pump."xsd:string |
| http://purl.uniprot.org/citations/22025725 | http://purl.uniprot.org/core/volume | "108"xsd:string |
| http://purl.uniprot.org/citations/22025725 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22025725 |
| http://purl.uniprot.org/citations/22025725 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22025725 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGX4-mappedCitation-22025725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22025725 |
| http://purl.uniprot.org/uniprot/#_Q8CGD9-mappedCitation-22025725 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22025725 |