| http://purl.uniprot.org/citations/22028379 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22028379 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcription factor IRF3-mediated type I interferon induction is essential for antiviral innate immunity. We identified the deSUMOylating enzyme Sentrin/SUMO-specific protease (SENP) 2 as a negative regulator of virus-triggered IFN-β induction. Overexpression of SENP2 caused IRF3 deSUMOylation, K48-linked ubiquitination, and degradation, whereas depletion of SENP2 had opposite effects. Both the SUMOylation and K48-linked ubiquitination of IRF3 occurred at lysines 70 and 87, and these processes are competitive. The level of virus-triggered IFN-β was markedly up-regulated and viral replication was reduced in SENP2-deficient cells comparing with wild-type controls. Our findings suggest that SENP2 regulates antiviral innate immunity by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation, and provide an example of cross-talk between the ubiquitin and SUMO pathways in innate immunity."xsd:string |
| http://purl.uniprot.org/citations/22028379 | http://purl.org/dc/terms/identifier | "doi:10.1093/jmcb/mjr020"xsd:string |
| http://purl.uniprot.org/citations/22028379 | http://purl.uniprot.org/core/author | "Liu L.J."xsd:string |
| http://purl.uniprot.org/citations/22028379 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/22028379 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/22028379 | http://purl.uniprot.org/core/author | "Ran Y."xsd:string |
| http://purl.uniprot.org/citations/22028379 | http://purl.uniprot.org/core/author | "Zhou Q."xsd:string |
| http://purl.uniprot.org/citations/22028379 | http://purl.uniprot.org/core/author | "Liu T.T."xsd:string |
| http://purl.uniprot.org/citations/22028379 | http://purl.uniprot.org/core/author | "Cheng J.K."xsd:string |
| http://purl.uniprot.org/citations/22028379 | http://purl.uniprot.org/core/author | "Shu H.B."xsd:string |
| http://purl.uniprot.org/citations/22028379 | http://purl.uniprot.org/core/author | "Mao A.P."xsd:string |
| http://purl.uniprot.org/citations/22028379 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22028379 | http://purl.uniprot.org/core/name | "J Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/22028379 | http://purl.uniprot.org/core/pages | "283-292"xsd:string |
| http://purl.uniprot.org/citations/22028379 | http://purl.uniprot.org/core/title | "SENP2 negatively regulates cellular antiviral response by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation."xsd:string |
| http://purl.uniprot.org/citations/22028379 | http://purl.uniprot.org/core/volume | "3"xsd:string |
| http://purl.uniprot.org/citations/22028379 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22028379 |
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