| http://purl.uniprot.org/citations/22028667 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22028667 | http://www.w3.org/2000/01/rdf-schema#comment | "RNA polymerase II synthesizes a diverse set of transcripts including both protein-coding and non-coding RNAs. One major difference between these two classes of transcripts is the mechanism of termination. Messenger RNA transcripts terminate downstream of the coding region in a process that is coupled to cleavage and polyadenylation reactions. Non-coding transcripts like Saccharomyces cerevisiae snoRNAs terminate in a process that requires the RNA-binding proteins Nrd1, Nab3, and Sen1. We report here the transcriptome-wide distribution of these termination factors. These data sets derived from in vivo protein-RNA cross-linking provide high-resolution definition of non-poly(A) terminators, identify novel genes regulated by attenuation of nascent transcripts close to the promoter, and demonstrate the widespread occurrence of Nrd1-bound 3' antisense transcripts on genes that are poorly expressed. In addition, we show that Sen1 does not cross-link efficiently to many expected non-coding RNAs but does cross-link to the 3' end of most pre-mRNA transcripts, suggesting an extensive role in mRNA 3' end formation and/or termination."xsd:string |
| http://purl.uniprot.org/citations/22028667 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1002329"xsd:string |
| http://purl.uniprot.org/citations/22028667 | http://purl.uniprot.org/core/author | "Corden J.L."xsd:string |
| http://purl.uniprot.org/citations/22028667 | http://purl.uniprot.org/core/author | "Hao H."xsd:string |
| http://purl.uniprot.org/citations/22028667 | http://purl.uniprot.org/core/author | "Wheelan S.J."xsd:string |
| http://purl.uniprot.org/citations/22028667 | http://purl.uniprot.org/core/author | "Jamonnak N."xsd:string |
| http://purl.uniprot.org/citations/22028667 | http://purl.uniprot.org/core/author | "Creamer T.J."xsd:string |
| http://purl.uniprot.org/citations/22028667 | http://purl.uniprot.org/core/author | "Darby M.M."xsd:string |
| http://purl.uniprot.org/citations/22028667 | http://purl.uniprot.org/core/author | "Schaughency P."xsd:string |
| http://purl.uniprot.org/citations/22028667 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22028667 | http://purl.uniprot.org/core/name | "PLoS Genet"xsd:string |
| http://purl.uniprot.org/citations/22028667 | http://purl.uniprot.org/core/pages | "e1002329"xsd:string |
| http://purl.uniprot.org/citations/22028667 | http://purl.uniprot.org/core/title | "Transcriptome-wide binding sites for components of the Saccharomyces cerevisiae non-poly(A) termination pathway: Nrd1, Nab3, and Sen1."xsd:string |
| http://purl.uniprot.org/citations/22028667 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/22028667 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22028667 |
| http://purl.uniprot.org/citations/22028667 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22028667 |
| http://purl.uniprot.org/uniprot/#_P14120-mappedCitation-22028667 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22028667 |
| http://purl.uniprot.org/uniprot/#_A0A8H4BVN9-mappedCitation-22028667 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22028667 |
| http://purl.uniprot.org/uniprot/#_A0A8H4BXU8-mappedCitation-22028667 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22028667 |
| http://purl.uniprot.org/uniprot/#_A0A7I9G4M2-mappedCitation-22028667 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22028667 |
| http://purl.uniprot.org/uniprot/#_P38996-mappedCitation-22028667 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22028667 |
| http://purl.uniprot.org/uniprot/#_P39081-mappedCitation-22028667 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22028667 |
| http://purl.uniprot.org/uniprot/#_P02406-mappedCitation-22028667 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22028667 |
| http://purl.uniprot.org/uniprot/#_P38625-mappedCitation-22028667 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22028667 |