| http://purl.uniprot.org/citations/22028796 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22028796 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22028796 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously reported that Candida albicans cell surface protein Hyr1 encodes a phagocyte killing resistance factor and active vaccination with a recombinant N-terminus of Hyr1 protein (rHyr1p-N), significantly protects immunocompetent mice from disseminated candidiasis. Here we report the marked efficacy of rHyr1p-N vaccine on improving the survival and reducing the fungal burden of disseminated candidiasis in both immunocompetent and immunocompromised mice using the FDA-approved adjuvant, alum. Importantly, we also show that pooled rabbit anti-Hyr1p polyclonal antibodies raised against 8 different peptide regions of rHyr1p-N protected mice in a hematogenously disseminated candidiasis model, raising the possibility of developing a successful passive immunotherapy strategy to treat this disease. Our data suggest that the rabbit anti-Hyr1p antibodies directly neutralized the Hyr1p virulence function, rather than enhanced opsonophagocytosis for subsequent killing by neutrophil in vitro. Finally, the rHyr1p-N vaccine was protective against non-albicans Candida spp. These preclinical data demonstrate that rHyr1p-N is likely to be a novel target for developing both active and passive immunization strategies against Candida infections."xsd:string |
| http://purl.uniprot.org/citations/22028796 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0025909"xsd:string |
| http://purl.uniprot.org/citations/22028796 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0025909"xsd:string |
| http://purl.uniprot.org/citations/22028796 | http://purl.uniprot.org/core/author | "Fu Y."xsd:string |
| http://purl.uniprot.org/citations/22028796 | http://purl.uniprot.org/core/author | "Fu Y."xsd:string |
| http://purl.uniprot.org/citations/22028796 | http://purl.uniprot.org/core/author | "Luo G."xsd:string |
| http://purl.uniprot.org/citations/22028796 | http://purl.uniprot.org/core/author | "Luo G."xsd:string |
| http://purl.uniprot.org/citations/22028796 | http://purl.uniprot.org/core/author | "Ibrahim A.S."xsd:string |
| http://purl.uniprot.org/citations/22028796 | http://purl.uniprot.org/core/author | "Ibrahim A.S."xsd:string |
| http://purl.uniprot.org/citations/22028796 | http://purl.uniprot.org/core/author | "Edwards J.E. Jr."xsd:string |
| http://purl.uniprot.org/citations/22028796 | http://purl.uniprot.org/core/author | "Edwards J.E. Jr."xsd:string |
| http://purl.uniprot.org/citations/22028796 | http://purl.uniprot.org/core/author | "French S.W."xsd:string |
| http://purl.uniprot.org/citations/22028796 | http://purl.uniprot.org/core/author | "French S.W."xsd:string |
| http://purl.uniprot.org/citations/22028796 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22028796 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22028796 | http://purl.uniprot.org/core/name | "PLoS ONE"xsd:string |
| http://purl.uniprot.org/citations/22028796 | http://purl.uniprot.org/core/name | "PLoS ONE"xsd:string |
| http://purl.uniprot.org/citations/22028796 | http://purl.uniprot.org/core/pages | "E25909"xsd:string |
| http://purl.uniprot.org/citations/22028796 | http://purl.uniprot.org/core/pages | "E25909"xsd:string |
| http://purl.uniprot.org/citations/22028796 | http://purl.uniprot.org/core/title | "Active and passive immunization with rHyr1p-N protects mice against hematogenously disseminated candidiasis."xsd:string |
| http://purl.uniprot.org/citations/22028796 | http://purl.uniprot.org/core/title | "Active and passive immunization with rHyr1p-N protects mice against hematogenously disseminated candidiasis."xsd:string |
| http://purl.uniprot.org/citations/22028796 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/22028796 | http://purl.uniprot.org/core/volume | "6"xsd:string |