| http://purl.uniprot.org/citations/22031541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22031541 | http://www.w3.org/2000/01/rdf-schema#comment | "Epithelial invagination is a common feature of embryogenesis. An example of invagination morphogenesis occurs during development of the early eye when the lens placode forms the lens pit. This morphogenesis is accompanied by a columnar-to-conical cell shape change (apical constriction or AC) and is known to be dependent on the cytoskeletal protein Shroom3. Because Shroom3-induced AC can be Rock1/2 dependent, we hypothesized that during lens invagination, RhoA, Rock and a RhoA guanine nucleotide exchange factor (RhoA-GEF) would also be required. In this study, we show that Rock activity is required for lens pit invagination and that RhoA activity is required for Shroom3-induced AC. We demonstrate that RhoA, when activated and targeted apically, is sufficient to induce AC and that RhoA plays a key role in Shroom3 apical localization. Furthermore, we identify Trio as a RhoA-GEF required for Shroom3-dependent AC in MDCK cells and in the lens pit. Collectively, these data indicate that a Trio-RhoA-Shroom3 pathway is required for AC during lens pit invagination."xsd:string |
| http://purl.uniprot.org/citations/22031541 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.067868"xsd:string |
| http://purl.uniprot.org/citations/22031541 | http://purl.uniprot.org/core/author | "Zheng Y."xsd:string |
| http://purl.uniprot.org/citations/22031541 | http://purl.uniprot.org/core/author | "Yang C."xsd:string |
| http://purl.uniprot.org/citations/22031541 | http://purl.uniprot.org/core/author | "Debant A."xsd:string |
| http://purl.uniprot.org/citations/22031541 | http://purl.uniprot.org/core/author | "Lang R.A."xsd:string |
| http://purl.uniprot.org/citations/22031541 | http://purl.uniprot.org/core/author | "Shang X."xsd:string |
| http://purl.uniprot.org/citations/22031541 | http://purl.uniprot.org/core/author | "Lou M."xsd:string |
| http://purl.uniprot.org/citations/22031541 | http://purl.uniprot.org/core/author | "Plageman T.F. Jr."xsd:string |
| http://purl.uniprot.org/citations/22031541 | http://purl.uniprot.org/core/author | "Jaudon F."xsd:string |
| http://purl.uniprot.org/citations/22031541 | http://purl.uniprot.org/core/author | "Hildebrand J.D."xsd:string |
| http://purl.uniprot.org/citations/22031541 | http://purl.uniprot.org/core/author | "Chauhan B.K."xsd:string |
| http://purl.uniprot.org/citations/22031541 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22031541 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/22031541 | http://purl.uniprot.org/core/pages | "5177-5188"xsd:string |
| http://purl.uniprot.org/citations/22031541 | http://purl.uniprot.org/core/title | "A Trio-RhoA-Shroom3 pathway is required for apical constriction and epithelial invagination."xsd:string |
| http://purl.uniprot.org/citations/22031541 | http://purl.uniprot.org/core/volume | "138"xsd:string |
| http://purl.uniprot.org/citations/22031541 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22031541 |
| http://purl.uniprot.org/citations/22031541 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22031541 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWJ1-mappedCitation-22031541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22031541 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXF6-mappedCitation-22031541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22031541 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BRP6-mappedCitation-22031541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22031541 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BS12-mappedCitation-22031541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22031541 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BPR4-mappedCitation-22031541 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22031541 |