| http://purl.uniprot.org/citations/22031882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22031882 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22031882 | http://www.w3.org/2000/01/rdf-schema#comment | "Although transcription factors are known to regulate synaptic plasticity, downstream genes that contribute to neural circuit remodeling are largely undefined. In Caenorhabditis elegans, GABAergic Dorsal D (DD) motor neuron synapses are relocated to new sites during larval development. This remodeling program is blocked in Ventral D (VD) GABAergic motor neurons by the COUP-TF (chicken ovalbumin upstream promoter transcription factor) homolog, UNC-55. We exploited this UNC-55 function to identify downstream synaptic remodeling genes that encode a diverse array of protein types including ion channels, cytoskeletal components, and transcription factors. We show that one of these targets, the Iroquois-like homeodomain protein, IRX-1, functions as a key regulator of remodeling in DD neurons. Our discovery of irx-1 as an unc-55-regulated target defines a transcriptional pathway that orchestrates an intricate synaptic remodeling program. Moreover, the well established roles of these conserved transcription factors in mammalian neural development suggest that a similar cascade may also control synaptic plasticity in more complex nervous systems."xsd:string |
| http://purl.uniprot.org/citations/22031882 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.3181-11.2011"xsd:string |
| http://purl.uniprot.org/citations/22031882 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.3181-11.2011"xsd:string |
| http://purl.uniprot.org/citations/22031882 | http://purl.uniprot.org/core/author | "Watson J.D."xsd:string |
| http://purl.uniprot.org/citations/22031882 | http://purl.uniprot.org/core/author | "Watson J.D."xsd:string |
| http://purl.uniprot.org/citations/22031882 | http://purl.uniprot.org/core/author | "Miller D.M. III"xsd:string |
| http://purl.uniprot.org/citations/22031882 | http://purl.uniprot.org/core/author | "Miller D.M. III"xsd:string |
| http://purl.uniprot.org/citations/22031882 | http://purl.uniprot.org/core/author | "Richmond J.E."xsd:string |
| http://purl.uniprot.org/citations/22031882 | http://purl.uniprot.org/core/author | "Richmond J.E."xsd:string |
| http://purl.uniprot.org/citations/22031882 | http://purl.uniprot.org/core/author | "Petersen S.C."xsd:string |
| http://purl.uniprot.org/citations/22031882 | http://purl.uniprot.org/core/author | "Petersen S.C."xsd:string |
| http://purl.uniprot.org/citations/22031882 | http://purl.uniprot.org/core/author | "Sarov M."xsd:string |
| http://purl.uniprot.org/citations/22031882 | http://purl.uniprot.org/core/author | "Sarov M."xsd:string |
| http://purl.uniprot.org/citations/22031882 | http://purl.uniprot.org/core/author | "Walthall W.W."xsd:string |
| http://purl.uniprot.org/citations/22031882 | http://purl.uniprot.org/core/author | "Walthall W.W."xsd:string |
| http://purl.uniprot.org/citations/22031882 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22031882 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22031882 | http://purl.uniprot.org/core/name | "J. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/22031882 | http://purl.uniprot.org/core/name | "J. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/22031882 | http://purl.uniprot.org/core/pages | "15362-15375"xsd:string |
| http://purl.uniprot.org/citations/22031882 | http://purl.uniprot.org/core/pages | "15362-15375"xsd:string |
| http://purl.uniprot.org/citations/22031882 | http://purl.uniprot.org/core/title | "A transcriptional program promotes remodeling of GABAergic synapses in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/22031882 | http://purl.uniprot.org/core/title | "A transcriptional program promotes remodeling of GABAergic synapses in Caenorhabditis elegans."xsd:string |