| http://purl.uniprot.org/citations/22033933 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22033933 | http://www.w3.org/2000/01/rdf-schema#comment | "Peroxisome proliferator activated receptor α (PPARα) is a distinctive marker of the brown fat phenotype that has been proposed to coordinate the transcriptional activation of genes for lipid oxidation and for thermogenic uncoupling protein 1 in brown adipose tissue. Here, we investigated the involvement of PPARα in the transcriptional control of the PPARγ coactivator (PGC)-1α gene. Treatment with PPARα agonists induced PGC-1α mRNA expression in brown fat in vivo and in primary brown adipocytes. This enhancement of PGC-1α transcription was mediated by PPARα binding to a PPAR-responsive element in the distal PGC-1α gene promoter. PGC-1α gene expression was decreased in PPARα-null brown fat, both under basal conditions and in response to thermogenic activation. Moreover, PPARα- and cAMP-mediated pathways interacted to control PGC-1α transcription. PRDM16 (PRD1-BF1-RIZ1 homologous domain-containing 16) promoted PPARα induction of PGC-1α gene transcription, especially under conditions in which protein kinase A pathways were activated. This enhancement was associated with the interaction of PRDM16 with the PGC-1α promoter at the PPARα-binding site. In addition, PPARα promoted the expression of the PRDM16 gene in brown adipocytes, and activation of PPARα in human white adipocytes led to the appearance of a brown adipocyte pattern of gene expression, including induction of PGC-1α and PRDM16. Collectively, these results suggest that PPARα acts as a key component of brown fat thermogenesis by coordinately regulating lipid catabolism and thermogenic gene expression via induction of PGC-1α and PRDM16."xsd:string |
| http://purl.uniprot.org/citations/22033933 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m111.252775"xsd:string |
| http://purl.uniprot.org/citations/22033933 | http://purl.uniprot.org/core/author | "Villarroya F."xsd:string |
| http://purl.uniprot.org/citations/22033933 | http://purl.uniprot.org/core/author | "Rosell M."xsd:string |
| http://purl.uniprot.org/citations/22033933 | http://purl.uniprot.org/core/author | "Monsalve M."xsd:string |
| http://purl.uniprot.org/citations/22033933 | http://purl.uniprot.org/core/author | "Hondares E."xsd:string |
| http://purl.uniprot.org/citations/22033933 | http://purl.uniprot.org/core/author | "Olmos Y."xsd:string |
| http://purl.uniprot.org/citations/22033933 | http://purl.uniprot.org/core/author | "Iglesias R."xsd:string |
| http://purl.uniprot.org/citations/22033933 | http://purl.uniprot.org/core/author | "Giralt M."xsd:string |
| http://purl.uniprot.org/citations/22033933 | http://purl.uniprot.org/core/author | "Diaz-Delfin J."xsd:string |
| http://purl.uniprot.org/citations/22033933 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22033933 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/22033933 | http://purl.uniprot.org/core/pages | "43112-43122"xsd:string |
| http://purl.uniprot.org/citations/22033933 | http://purl.uniprot.org/core/title | "Peroxisome proliferator-activated receptor alpha (PPARalpha) induces PPARgamma coactivator 1alpha (PGC-1alpha) gene expression and contributes to thermogenic activation of brown fat: involvement of PRDM16."xsd:string |
| http://purl.uniprot.org/citations/22033933 | http://purl.uniprot.org/core/volume | "286"xsd:string |
| http://purl.uniprot.org/citations/22033933 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22033933 |
| http://purl.uniprot.org/citations/22033933 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22033933 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGG3-mappedCitation-22033933 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22033933 |
| http://purl.uniprot.org/uniprot/#_A2A929-mappedCitation-22033933 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22033933 |
| http://purl.uniprot.org/uniprot/#_A2A930-mappedCitation-22033933 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22033933 |
| http://purl.uniprot.org/uniprot/#_A2A931-mappedCitation-22033933 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22033933 |
| http://purl.uniprot.org/uniprot/#_A2A933-mappedCitation-22033933 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22033933 |
| http://purl.uniprot.org/uniprot/#_A2A934-mappedCitation-22033933 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22033933 |
| http://purl.uniprot.org/uniprot/#_A2A935-mappedCitation-22033933 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22033933 |