| http://purl.uniprot.org/citations/22036506 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22036506 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22036506 | http://www.w3.org/2000/01/rdf-schema#comment | "Rac1 small GTPase controls essential aspects of cell biology and is a direct target of numerous bacterial virulence factors. The CNF1 toxin of pathogenic Escherichia coli addresses Rac1 to ubiquitin-proteasome system (UPS). We report the essential role of the tumor suppressor HACE1, a HECT-domain containing E3 ubiquitin-ligase, in the targeting of Rac1 to UPS. HACE1 binds preferentially GTP-bound Rac1 and catalyzes its polyubiquitylation. HACE1 expression increases the ubiquitylation of Rac1, when the GTPase is activated by point mutations or by the GEF-domain of Dbl. RNAi-mediated depletion of HACE1 blocks the ubiquitylation of active Rac1 and increases GTP-bound Rac1 cellular levels. HACE1 antagonizes cell isotropic spreading, a hallmark of Rac1 activation, and is required for endothelial cell monolayer invasion by bacteria. Together, these data establish the role of the HACE1 E3 ubiquitin-ligase in controlling Rac1 ubiquitylation and activity."xsd:string |
| http://purl.uniprot.org/citations/22036506 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2011.08.015"xsd:string |
| http://purl.uniprot.org/citations/22036506 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2011.08.015"xsd:string |
| http://purl.uniprot.org/citations/22036506 | http://purl.uniprot.org/core/author | "Boyer L."xsd:string |
| http://purl.uniprot.org/citations/22036506 | http://purl.uniprot.org/core/author | "Boyer L."xsd:string |
| http://purl.uniprot.org/citations/22036506 | http://purl.uniprot.org/core/author | "Mettouchi A."xsd:string |
| http://purl.uniprot.org/citations/22036506 | http://purl.uniprot.org/core/author | "Mettouchi A."xsd:string |
| http://purl.uniprot.org/citations/22036506 | http://purl.uniprot.org/core/author | "Stefani C."xsd:string |
| http://purl.uniprot.org/citations/22036506 | http://purl.uniprot.org/core/author | "Stefani C."xsd:string |
| http://purl.uniprot.org/citations/22036506 | http://purl.uniprot.org/core/author | "Gacon G."xsd:string |
| http://purl.uniprot.org/citations/22036506 | http://purl.uniprot.org/core/author | "Gacon G."xsd:string |
| http://purl.uniprot.org/citations/22036506 | http://purl.uniprot.org/core/author | "Lemichez E."xsd:string |
| http://purl.uniprot.org/citations/22036506 | http://purl.uniprot.org/core/author | "Lemichez E."xsd:string |
| http://purl.uniprot.org/citations/22036506 | http://purl.uniprot.org/core/author | "Visvikis O."xsd:string |
| http://purl.uniprot.org/citations/22036506 | http://purl.uniprot.org/core/author | "Visvikis O."xsd:string |
| http://purl.uniprot.org/citations/22036506 | http://purl.uniprot.org/core/author | "Bertoglio J."xsd:string |
| http://purl.uniprot.org/citations/22036506 | http://purl.uniprot.org/core/author | "Bertoglio J."xsd:string |
| http://purl.uniprot.org/citations/22036506 | http://purl.uniprot.org/core/author | "Doye A."xsd:string |
| http://purl.uniprot.org/citations/22036506 | http://purl.uniprot.org/core/author | "Doye A."xsd:string |
| http://purl.uniprot.org/citations/22036506 | http://purl.uniprot.org/core/author | "Munro P."xsd:string |
| http://purl.uniprot.org/citations/22036506 | http://purl.uniprot.org/core/author | "Munro P."xsd:string |
| http://purl.uniprot.org/citations/22036506 | http://purl.uniprot.org/core/author | "Torrino S."xsd:string |
| http://purl.uniprot.org/citations/22036506 | http://purl.uniprot.org/core/author | "Torrino S."xsd:string |