| http://purl.uniprot.org/citations/22037414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22037414 | http://www.w3.org/2000/01/rdf-schema#comment | "Caspase 8 initiates apoptosis downstream of TNF death receptors by undergoing autocleavage and processing the executioner caspase 3 (ref. 1). However, the dominant function of caspase 8 is to transmit a pro-survival signal that suppresses programmed necrosis (or necroptosis) mediated by RIPK1 and RIPK3 (refs 2-6) during embryogenesis and haematopoiesis(7-9). Suppression of necrotic cell death by caspase 8 requires its catalytic activity but not the autocleavage essential for apoptosis(10); however, the key substrate processed by caspase 8 to block necrosis has been elusive. A key substrate must meet three criteria: it must be essential for programmed necrosis; it must be cleaved by caspase 8 in situations where caspase 8 is blocking necrosis; and mutation of the caspase 8 processing site on the substrate should convert a pro-survival response to necrotic death without the need for caspase 8 inhibition. We now identify CYLD as a substrate for caspase 8 that satisfies these criteria. Following TNF stimulation, caspase 8 cleaves CYLD to generate a survival signal. In contrast, loss of caspase 8 prevented CYLD degradation, resulting in necrotic death. A CYLD substitution mutation at Asp 215 that cannot be cleaved by caspase 8 switches cell survival to necrotic cell death in response to TNF."xsd:string |
| http://purl.uniprot.org/citations/22037414 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb2362"xsd:string |
| http://purl.uniprot.org/citations/22037414 | http://purl.uniprot.org/core/author | "Xavier R."xsd:string |
| http://purl.uniprot.org/citations/22037414 | http://purl.uniprot.org/core/author | "Ng A."xsd:string |
| http://purl.uniprot.org/citations/22037414 | http://purl.uniprot.org/core/author | "Green D.R."xsd:string |
| http://purl.uniprot.org/citations/22037414 | http://purl.uniprot.org/core/author | "Massoumi R."xsd:string |
| http://purl.uniprot.org/citations/22037414 | http://purl.uniprot.org/core/author | "O'Donnell M.A."xsd:string |
| http://purl.uniprot.org/citations/22037414 | http://purl.uniprot.org/core/author | "Ting A.T."xsd:string |
| http://purl.uniprot.org/citations/22037414 | http://purl.uniprot.org/core/author | "Oberst A."xsd:string |
| http://purl.uniprot.org/citations/22037414 | http://purl.uniprot.org/core/author | "Perez-Jimenez E."xsd:string |
| http://purl.uniprot.org/citations/22037414 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22037414 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/22037414 | http://purl.uniprot.org/core/pages | "1437-1442"xsd:string |
| http://purl.uniprot.org/citations/22037414 | http://purl.uniprot.org/core/title | "Caspase 8 inhibits programmed necrosis by processing CYLD."xsd:string |
| http://purl.uniprot.org/citations/22037414 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/22037414 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22037414 |
| http://purl.uniprot.org/citations/22037414 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22037414 |
| http://purl.uniprot.org/uniprot/O89110#attribution-954C2223529D6F48B20F0F165D3AFCBE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22037414 |
| http://purl.uniprot.org/uniprot/Q80TQ2#attribution-F38741905A16984A217E81BE58768961 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22037414 |
| http://purl.uniprot.org/uniprot/P06804#attribution-954C2223529D6F48B20F0F165D3AFCBE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22037414 |
| http://purl.uniprot.org/uniprot/#_A0A087WQT6-mappedCitation-22037414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22037414 |
| http://purl.uniprot.org/uniprot/#_D3YYY3-mappedCitation-22037414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22037414 |
| http://purl.uniprot.org/uniprot/#_E9PZP3-mappedCitation-22037414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22037414 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J210-mappedCitation-22037414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22037414 |