| http://purl.uniprot.org/citations/22037487 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22037487 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22037487 | http://www.w3.org/2000/01/rdf-schema#comment | "PLEKHA5 (pleckstrin homology domain-containing protein family A, member 5) belongs to the PLEKHA family (PLEKHA1-6); however, the properties of this protein remain poorly characterized. We have identified and characterized two forms of PLEKHA5 mRNA. The long form of PLEKHA5 (L-PLEKHA5) contains 32 exons, encodes 1282 amino acids, and is specifically expressed in the brain; the short form of PLEKHA5 (S-PLEKHA5) is generated by alternative splicing of L-PLEKHA5, contains 26 exons, encodes 1116 amino acids, and is ubiquitously expressed. Both forms of the protein contain putative Trp-Trp (WW) and pleckstrin homology (PH) domains and are located mainly in the cytosol. Developmental and age-dependent expression studies in the mouse brain have shown that Plekha5 is the most abundantly expressed protein at E13.5 with S-Plekha5 dominancy. L-Plekha5 levels increased gradually with the decrease in total Plekha5 levels; moreover, L-Plekha5 became the dominant protein at E17.5, maintaining its dominance throughout adulthood. Protein-lipid overlay assays have indicated that the PH domain of PLEKHA5 specifically interacts with PI3P, PI4P, PI5P, and PI(3,5)P2. These results suggest that the S-to L-conversion of PLEKHA5 (Plekha5) may play an important role in brain development through association with specific phosphoinositides."xsd:string |
| http://purl.uniprot.org/citations/22037487 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.gene.2011.10.018"xsd:string |
| http://purl.uniprot.org/citations/22037487 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.gene.2011.10.018"xsd:string |
| http://purl.uniprot.org/citations/22037487 | http://purl.uniprot.org/core/author | "Nomura N."xsd:string |
| http://purl.uniprot.org/citations/22037487 | http://purl.uniprot.org/core/author | "Nomura N."xsd:string |
| http://purl.uniprot.org/citations/22037487 | http://purl.uniprot.org/core/author | "Yamada Y."xsd:string |
| http://purl.uniprot.org/citations/22037487 | http://purl.uniprot.org/core/author | "Yamada Y."xsd:string |
| http://purl.uniprot.org/citations/22037487 | http://purl.uniprot.org/core/author | "Yamada K."xsd:string |
| http://purl.uniprot.org/citations/22037487 | http://purl.uniprot.org/core/author | "Yamada K."xsd:string |
| http://purl.uniprot.org/citations/22037487 | http://purl.uniprot.org/core/author | "Yamano A."xsd:string |
| http://purl.uniprot.org/citations/22037487 | http://purl.uniprot.org/core/author | "Yamano A."xsd:string |
| http://purl.uniprot.org/citations/22037487 | http://purl.uniprot.org/core/author | "Wakamatsu N."xsd:string |
| http://purl.uniprot.org/citations/22037487 | http://purl.uniprot.org/core/author | "Wakamatsu N."xsd:string |
| http://purl.uniprot.org/citations/22037487 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22037487 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22037487 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/22037487 | http://purl.uniprot.org/core/name | "Gene"xsd:string |
| http://purl.uniprot.org/citations/22037487 | http://purl.uniprot.org/core/pages | "270-275"xsd:string |
| http://purl.uniprot.org/citations/22037487 | http://purl.uniprot.org/core/pages | "270-275"xsd:string |
| http://purl.uniprot.org/citations/22037487 | http://purl.uniprot.org/core/title | "Identification and characterization of splicing variants of PLEKHA5 (Plekha5) during brain development."xsd:string |
| http://purl.uniprot.org/citations/22037487 | http://purl.uniprot.org/core/title | "Identification and characterization of splicing variants of PLEKHA5 (Plekha5) during brain development."xsd:string |
| http://purl.uniprot.org/citations/22037487 | http://purl.uniprot.org/core/volume | "492"xsd:string |
| http://purl.uniprot.org/citations/22037487 | http://purl.uniprot.org/core/volume | "492"xsd:string |