| http://purl.uniprot.org/citations/22038056 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22038056 | http://www.w3.org/2000/01/rdf-schema#comment | "Several potential sources of reactive oxygen species (ROS) in cells exist. One source is NADPH oxidase, which is especially important for superoxide radical production. Nox2 is a primary regulatory subunit of NADPH oxidase. In the present study, we examined the role of ROS and NADPH oxidase in ischemic preconditioning (IP)-mediated cardioprotection by using Nox2(-/-) mice. Both wild-type (WT) and Nox2(-/-) mice were subjected to either 30 min of ischemia followed by 2 h of reperfusion (IR) or IP prior to 30 min ischemia and 2 h of reperfusion. Reduction in left ventricular developed pressure (60.1 versus 63 mmHg), dp/dt (max) (893 versus 1,027 mmHg/s), and aortic flow (0.9 versus 1.8 ml/min) was observed in Nox2(-/-)IPIR compared to WTIPIR along with increased infarct size (33% versus 22%) and apoptosis after 120 min of reperfusion. Differentially regulated genes were demonstrated by comparing gene expression in WTIPIR versus Nox2(-/-) IPIR hearts. Selected differentially regulated genes such as β-catenin, SRPK3, ERDR1, ACIN1, Syntaxin-8, and STC1 were validated by real-time PCR. Taken together, this is the first report identifying important, differentially expressed genes during ischemic preconditioning in Nox2(-/-) mice by using microarray analysis."xsd:string |
| http://purl.uniprot.org/citations/22038056 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10142-011-0256-x"xsd:string |
| http://purl.uniprot.org/citations/22038056 | http://purl.uniprot.org/core/author | "Kaur A."xsd:string |
| http://purl.uniprot.org/citations/22038056 | http://purl.uniprot.org/core/author | "Hager J."xsd:string |
| http://purl.uniprot.org/citations/22038056 | http://purl.uniprot.org/core/author | "Zhan L."xsd:string |
| http://purl.uniprot.org/citations/22038056 | http://purl.uniprot.org/core/author | "Adluri R.S."xsd:string |
| http://purl.uniprot.org/citations/22038056 | http://purl.uniprot.org/core/author | "Maulik G."xsd:string |
| http://purl.uniprot.org/citations/22038056 | http://purl.uniprot.org/core/author | "Maulik N."xsd:string |
| http://purl.uniprot.org/citations/22038056 | http://purl.uniprot.org/core/author | "Sanchez J.A."xsd:string |
| http://purl.uniprot.org/citations/22038056 | http://purl.uniprot.org/core/author | "Thirunavukkarasu M."xsd:string |
| http://purl.uniprot.org/citations/22038056 | http://purl.uniprot.org/core/author | "Samuel S.M."xsd:string |
| http://purl.uniprot.org/citations/22038056 | http://purl.uniprot.org/core/author | "Juhasz B."xsd:string |
| http://purl.uniprot.org/citations/22038056 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22038056 | http://purl.uniprot.org/core/name | "Funct Integr Genomics"xsd:string |
| http://purl.uniprot.org/citations/22038056 | http://purl.uniprot.org/core/pages | "501-514"xsd:string |
| http://purl.uniprot.org/citations/22038056 | http://purl.uniprot.org/core/title | "Novel role of NADPH oxidase in ischemic myocardium: a study with Nox2 knockout mice."xsd:string |
| http://purl.uniprot.org/citations/22038056 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/22038056 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22038056 |
| http://purl.uniprot.org/citations/22038056 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22038056 |
| http://purl.uniprot.org/uniprot/#_E9Q7S3-mappedCitation-22038056 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22038056 |
| http://purl.uniprot.org/uniprot/#_E9Q802-mappedCitation-22038056 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22038056 |
| http://purl.uniprot.org/uniprot/#_Q3U4P0-mappedCitation-22038056 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22038056 |
| http://purl.uniprot.org/uniprot/#_Q3TVP4-mappedCitation-22038056 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22038056 |
| http://purl.uniprot.org/uniprot/#_Q61093-mappedCitation-22038056 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22038056 |