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| http://purl.uniprot.org/citations/22040290 | http://www.w3.org/2000/01/rdf-schema#comment | "MMP28 is constitutively expressed by epithelial cells in many tissues, including the respiratory epithelium in the lung and keratinocytes in the skin. This constitutive expression suggests that MMP28 may serve a role in epithelial cell homeostasis. In an effort to determine its function in epithelial cell biology, we generated cell lines expressing wild-type or catalytically-inactive mutant MMP28 in two pulmonary epithelial cell lines, A549 and BEAS-2B. We observed that over-expression of MMP28 provided protection against apoptosis induced by either serum-deprivation or treatment with a protein kinase inhibitor, staurosporine. Furthermore, we observed increased caspase-3/7 activity in influenza-infected lungs from Mmp28-/-mice compared to wild-type mice, and this activity localized to the airway epithelium but was not associated with a change in viral load. Thus, we have identified a novel role of MMP28 in promoting epithelial cell survival in the lung."xsd:string |
| http://purl.uniprot.org/citations/22040290 | http://purl.org/dc/terms/identifier | "doi:10.1186/1465-9921-12-144"xsd:string |
| http://purl.uniprot.org/citations/22040290 | http://purl.uniprot.org/core/author | "Parks W.C."xsd:string |
| http://purl.uniprot.org/citations/22040290 | http://purl.uniprot.org/core/author | "Chen A.J."xsd:string |
| http://purl.uniprot.org/citations/22040290 | http://purl.uniprot.org/core/author | "Manicone A.M."xsd:string |
| http://purl.uniprot.org/citations/22040290 | http://purl.uniprot.org/core/author | "Harju-Baker S."xsd:string |
| http://purl.uniprot.org/citations/22040290 | http://purl.uniprot.org/core/author | "Johnston L.K."xsd:string |
| http://purl.uniprot.org/citations/22040290 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22040290 | http://purl.uniprot.org/core/name | "Respir Res"xsd:string |
| http://purl.uniprot.org/citations/22040290 | http://purl.uniprot.org/core/pages | "144"xsd:string |
| http://purl.uniprot.org/citations/22040290 | http://purl.uniprot.org/core/title | "Epilysin (matrix metalloproteinase-28) contributes to airway epithelial cell survival."xsd:string |
| http://purl.uniprot.org/citations/22040290 | http://purl.uniprot.org/core/volume | "12"xsd:string |
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