| http://purl.uniprot.org/citations/2204115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2204115 | http://www.w3.org/2000/01/rdf-schema#comment | "The post-translational processing of the yeast a-mating pheromone precursor, Ras proteins, nuclear lamins, and some subunits of trimeric G proteins requires a set of complex modifications at their carboxyl termini. This processing includes three steps: prenylation of a cysteine residue, proteolytic processing, and carboxymethylation. In the yeast Saccharomyces cerevisiae, the product of the DPR1-RAM1 gene participates in this type of processing. Through the use of an in vitro assay with peptide substrates modeled after a presumptive a-mating pheromone precursor, it was discovered that mutations in DPR1-RAM1 cause a defect in the prenylation reaction. It was further shown that DPR1-RAM1 encodes an essential and limiting component of a protein prenyltransferase. These studies also implied a fixed order of the three processing steps shared by prenylated proteins: prenylation, proteolysis, then carboxymethylation. Because the yeast protein prenyltransferase could also prenylate human H-ras p21 precursor, the human DPR1-RAM1 analogue may be a useful target for anticancer chemotherapy."xsd:string |
| http://purl.uniprot.org/citations/2204115 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.2204115"xsd:string |
| http://purl.uniprot.org/citations/2204115 | http://purl.uniprot.org/core/author | "Kim S.H."xsd:string |
| http://purl.uniprot.org/citations/2204115 | http://purl.uniprot.org/core/author | "Poulter C.D."xsd:string |
| http://purl.uniprot.org/citations/2204115 | http://purl.uniprot.org/core/author | "Yang C.C."xsd:string |
| http://purl.uniprot.org/citations/2204115 | http://purl.uniprot.org/core/author | "Rosenberg S."xsd:string |
| http://purl.uniprot.org/citations/2204115 | http://purl.uniprot.org/core/author | "Rine J."xsd:string |
| http://purl.uniprot.org/citations/2204115 | http://purl.uniprot.org/core/author | "Schafer W.R."xsd:string |
| http://purl.uniprot.org/citations/2204115 | http://purl.uniprot.org/core/author | "Mayer M.P."xsd:string |
| http://purl.uniprot.org/citations/2204115 | http://purl.uniprot.org/core/author | "Trueblood C.E."xsd:string |
| http://purl.uniprot.org/citations/2204115 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/2204115 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/2204115 | http://purl.uniprot.org/core/pages | "1133-1139"xsd:string |
| http://purl.uniprot.org/citations/2204115 | http://purl.uniprot.org/core/title | "Enzymatic coupling of cholesterol intermediates to a mating pheromone precursor and to the ras protein."xsd:string |
| http://purl.uniprot.org/citations/2204115 | http://purl.uniprot.org/core/volume | "249"xsd:string |
| http://purl.uniprot.org/citations/2204115 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2204115 |
| http://purl.uniprot.org/citations/2204115 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/2204115 |
| http://purl.uniprot.org/uniprot/#_P22007-mappedCitation-2204115 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2204115 |
| http://purl.uniprot.org/uniprot/P22007 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/2204115 |