| http://purl.uniprot.org/citations/22043010 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22043010 | http://www.w3.org/2000/01/rdf-schema#comment | "Lymphocyte homing to, and motility within, lymph nodes is regulated by the chemokine receptor CCR7 and its two ligands CCL19 and CCL21. There, lymphocytes are exposed to a number of extracellular stimuli that influence cellular functions and determine the cell fate. In this study, we assessed the effect of TCR engagement on CCR7-mediated cell migration. We found that long-term TCR triggering of freshly isolated human T cells through CD3/CD28 attenuated CCR7-driven chemotaxis, whereas short-term activation significantly enhanced CCR7-mediated, but not CXCR4-mediated, migration efficiency. Short-term activation most prominently enhanced the migratory response of naive T cells of both CD4 and CD8 subsets. We identified distinct roles for Src family kinases in modulating CCR7-mediated T cell migration. We provide evidence that Fyn, together with Ca(2+)-independent protein kinase C isoforms, kept the migratory response of naive T cells toward CCL21 at a low level. In nonactivated T cells, CCR7 triggering induced a Fyn-dependent phosphorylation of the inhibitory Tyr505 of Lck. Inhibiting Fyn in these nonactivated T cells prevented the negative regulation of Lck and facilitated high CCR7-driven T cell chemotaxis. Moreover, we found that the enhanced migration of short-term activated T cells was accompanied by a synergistic, Src-dependent activation of the adaptor molecule linker for activation of T cells. Collectively, we characterize a cross-talk between the TCR and CCR7 and provide mechanistic evidence that the activation status of T cells controls lymphocyte motility and sets a threshold for their migratory response."xsd:string |
| http://purl.uniprot.org/citations/22043010 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1101850"xsd:string |
| http://purl.uniprot.org/citations/22043010 | http://purl.uniprot.org/core/author | "Singer E."xsd:string |
| http://purl.uniprot.org/citations/22043010 | http://purl.uniprot.org/core/author | "Hauser M.A."xsd:string |
| http://purl.uniprot.org/citations/22043010 | http://purl.uniprot.org/core/author | "Legler D.F."xsd:string |
| http://purl.uniprot.org/citations/22043010 | http://purl.uniprot.org/core/author | "Groettrup M."xsd:string |
| http://purl.uniprot.org/citations/22043010 | http://purl.uniprot.org/core/author | "Schaeuble K."xsd:string |
| http://purl.uniprot.org/citations/22043010 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22043010 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/22043010 | http://purl.uniprot.org/core/pages | "5645-5652"xsd:string |
| http://purl.uniprot.org/citations/22043010 | http://purl.uniprot.org/core/title | "Cross-talk between TCR and CCR7 signaling sets a temporal threshold for enhanced T lymphocyte migration."xsd:string |
| http://purl.uniprot.org/citations/22043010 | http://purl.uniprot.org/core/volume | "187"xsd:string |
| http://purl.uniprot.org/citations/22043010 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22043010 |
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