| http://purl.uniprot.org/citations/22049025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22049025 | http://www.w3.org/2000/01/rdf-schema#comment | "E-Cadherin-mediated formation of adherens junctions (AJs) is essential for the morphogenesis of epithelial cells. However, the mechanisms underlying E-cadherin clustering and AJ maturation are not fully understood. Here we report that type Iγ phosphatidylinositol-4-phosphate 5-kinase (PIPKIγ) associates with the exocyst via a direct interaction with Exo70, the exocyst subunit that guides the polarized targeting of exocyst to the plasma membrane. By means of this interaction, PIPKIγ mediates the association between E-cadherin and Exo70 and determines the targeting of Exo70 to AJs. Further investigation revealed that Exo70 is necessary for clustering of E-cadherin on the plasma membrane and extension of nascent E-cadherin adhesions, which are critical for the maturation of cohesive AJs. In addition, we observed phosphatidylinositol-4,5-bisphosphate (PI4,5P(2)) accumulation at E-cadherin clusters during the assembly of E-cadherin adhesions. PIPKIγ-generated PI4,5P(2) is required for recruiting Exo70 to newly formed E-cadherin junctions and facilitates the assembly and maturation of AJs. These results support a model in which PIPKIγ and PIPKIγ-generated PI4,5P(2) pools at nascent E-cadherin contacts cue Exo70 targeting and orient the tethering of exocyst-associated E-cadherin. This could be an important mechanism that regulates E-cadherin clustering and AJ maturation, which is essential for the establishment of solid, polarized epithelial structures."xsd:string |
| http://purl.uniprot.org/citations/22049025 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e11-05-0449"xsd:string |
| http://purl.uniprot.org/citations/22049025 | http://purl.uniprot.org/core/author | "Huang Y."xsd:string |
| http://purl.uniprot.org/citations/22049025 | http://purl.uniprot.org/core/author | "Hu J."xsd:string |
| http://purl.uniprot.org/citations/22049025 | http://purl.uniprot.org/core/author | "Xu Q."xsd:string |
| http://purl.uniprot.org/citations/22049025 | http://purl.uniprot.org/core/author | "Xiong X."xsd:string |
| http://purl.uniprot.org/citations/22049025 | http://purl.uniprot.org/core/author | "Anderson R."xsd:string |
| http://purl.uniprot.org/citations/22049025 | http://purl.uniprot.org/core/author | "Ling K."xsd:string |
| http://purl.uniprot.org/citations/22049025 | http://purl.uniprot.org/core/author | "Singh R.D."xsd:string |
| http://purl.uniprot.org/citations/22049025 | http://purl.uniprot.org/core/author | "Leof E."xsd:string |
| http://purl.uniprot.org/citations/22049025 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22049025 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/22049025 | http://purl.uniprot.org/core/pages | "87-98"xsd:string |
| http://purl.uniprot.org/citations/22049025 | http://purl.uniprot.org/core/title | "An association between type Igamma PI4P 5-kinase and Exo70 directs E-cadherin clustering and epithelial polarization."xsd:string |
| http://purl.uniprot.org/citations/22049025 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/22049025 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22049025 |
| http://purl.uniprot.org/citations/22049025 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22049025 |
| http://purl.uniprot.org/uniprot/#_A0A0E3XJU3-mappedCitation-22049025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22049025 |
| http://purl.uniprot.org/uniprot/#_A0A0U2ZQU7-mappedCitation-22049025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22049025 |
| http://purl.uniprot.org/uniprot/#_A0A140HMB1-mappedCitation-22049025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22049025 |
| http://purl.uniprot.org/uniprot/#_A0A3G2JNR5-mappedCitation-22049025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22049025 |
| http://purl.uniprot.org/uniprot/#_A0A6C0N5X1-mappedCitation-22049025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22049025 |
| http://purl.uniprot.org/uniprot/#_A5D8W4-mappedCitation-22049025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22049025 |
| http://purl.uniprot.org/uniprot/#_B3GN61-mappedCitation-22049025 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22049025 |