| http://purl.uniprot.org/citations/22051242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22051242 | http://www.w3.org/2000/01/rdf-schema#comment | "Oxidative stress contributes to the pathogenesis of aging-associated heart failure. Among various signaling pathways mediating oxidative stress, the NAD(+) -dependent protein deacetylase SirT1 has been implicated in the protection of heart muscle. Expression of a locally acting insulin-like growth factor-1 (IGF-1) propeptide (mIGF-1) helps the heart to recover from infarct and enhances SirT1 expression in cardiomyocytes (CM) in vitro, exerting protection from hypertrophic and oxidative stresses. To study the role of mIGF-1/SirT1 signaling in vivo, we generated cardiac-specific mIGF-1 transgenic mice in which SirT1 was depleted from adult CM in a tamoxifen-inducible and conditional fashion. Analysis of these mice confirmed that mIGF-1-induced SirT1 activity is necessary to protect the heart from paraquat (PQ)-induced oxidative stress and lethality. In cultured CM, mIGF-1 increases SirT1 expression through a c-Jun NH(2)-terminal protein kinase 1 (JNK1)-dependent signaling mechanism. Thus, mIGF-1 protects the heart from oxidative stress via SirT1/JNK1 activity, suggesting new avenues for cardiac therapy during aging and heart failure."xsd:string |
| http://purl.uniprot.org/citations/22051242 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1474-9726.2011.00766.x"xsd:string |
| http://purl.uniprot.org/citations/22051242 | http://purl.uniprot.org/core/author | "Martinez C."xsd:string |
| http://purl.uniprot.org/citations/22051242 | http://purl.uniprot.org/core/author | "Giuliani A."xsd:string |
| http://purl.uniprot.org/citations/22051242 | http://purl.uniprot.org/core/author | "Claycomb W.C."xsd:string |
| http://purl.uniprot.org/citations/22051242 | http://purl.uniprot.org/core/author | "Rosenthal N."xsd:string |
| http://purl.uniprot.org/citations/22051242 | http://purl.uniprot.org/core/author | "Pazienza V."xsd:string |
| http://purl.uniprot.org/citations/22051242 | http://purl.uniprot.org/core/author | "Vinciguerra M."xsd:string |
| http://purl.uniprot.org/citations/22051242 | http://purl.uniprot.org/core/author | "Santini M.P."xsd:string |
| http://purl.uniprot.org/citations/22051242 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22051242 | http://purl.uniprot.org/core/name | "Aging Cell"xsd:string |
| http://purl.uniprot.org/citations/22051242 | http://purl.uniprot.org/core/pages | "139-149"xsd:string |
| http://purl.uniprot.org/citations/22051242 | http://purl.uniprot.org/core/title | "mIGF-1/JNK1/SirT1 signaling confers protection against oxidative stress in the heart."xsd:string |
| http://purl.uniprot.org/citations/22051242 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/22051242 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22051242 |
| http://purl.uniprot.org/citations/22051242 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22051242 |
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