| http://purl.uniprot.org/citations/22055192 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22055192 | http://www.w3.org/2000/01/rdf-schema#comment | "Homeostatic control of oxygen availability allows cells to survive oxygen deprivation. Although the transcription factor hypoxia-inducible factor 1α (HIF-1α) is the main regulator of the hypoxic response, the upstream mechanisms required for its stabilization remain elusive. Here, we show that p75 neurotrophin receptor (p75(NTR)) undergoes hypoxia-induced γ-secretase-dependent cleavage to provide a positive feed-forward mechanism required for oxygen-dependent HIF-1α stabilization. The intracellular domain of p75(NTR) directly interacts with the evolutionarily conserved zinc finger domains of the E3 RING ubiquitin ligase Siah2 (seven in absentia homolog 2), which regulates HIF-1α degradation. p75(NTR) stabilizes Siah2 by decreasing its auto-ubiquitination. Genetic loss of p75(NTR) dramatically decreases Siah2 abundance, HIF-1α stabilization, and induction of HIF-1α target genes in hypoxia. p75(NTR-/-) mice show reduced HIF-1α stabilization, vascular endothelial growth factor (VEGF) expression, and neoangiogenesis after retinal hypoxia. Thus, hypoxia-induced intramembrane proteolysis of p75(NTR) constitutes an apical oxygen-dependent mechanism to control the magnitude of the hypoxic response."xsd:string |
| http://purl.uniprot.org/citations/22055192 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2011.08.033"xsd:string |
| http://purl.uniprot.org/citations/22055192 | http://purl.uniprot.org/core/author | "Houslay M.D."xsd:string |
| http://purl.uniprot.org/citations/22055192 | http://purl.uniprot.org/core/author | "Akassoglou K."xsd:string |
| http://purl.uniprot.org/citations/22055192 | http://purl.uniprot.org/core/author | "Le Moan N."xsd:string |
| http://purl.uniprot.org/citations/22055192 | http://purl.uniprot.org/core/author | "Christian F."xsd:string |
| http://purl.uniprot.org/citations/22055192 | http://purl.uniprot.org/core/author | "Houslay D.M."xsd:string |
| http://purl.uniprot.org/citations/22055192 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22055192 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/22055192 | http://purl.uniprot.org/core/pages | "476-490"xsd:string |
| http://purl.uniprot.org/citations/22055192 | http://purl.uniprot.org/core/title | "Oxygen-dependent cleavage of the p75 neurotrophin receptor triggers stabilization of HIF-1alpha."xsd:string |
| http://purl.uniprot.org/citations/22055192 | http://purl.uniprot.org/core/volume | "44"xsd:string |
| http://purl.uniprot.org/citations/22055192 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22055192 |
| http://purl.uniprot.org/citations/22055192 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22055192 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1E9-mappedCitation-22055192 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22055192 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1F0-mappedCitation-22055192 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22055192 |
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| http://purl.uniprot.org/uniprot/#_Q8BYY1-mappedCitation-22055192 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22055192 |
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