| http://purl.uniprot.org/citations/22057932 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22057932 | http://www.w3.org/2000/01/rdf-schema#comment | "HAX-1 is a mitochondrial protein which acts as an antiapoptotic protein in HeLa- and Jurkat cells after Fas-treatment, irradiation or serum deprivation. This underlines the evidence that HAX-1 might be involved in several apoptotic pathways. In this context, it is known that cell death executed by cerebral ischemia involves both receptor- and mitochondrial apoptotic mechanisms. In this study, we performed focal cerebral ischemia in mice and investigated principally the dynamic changes of HAX-1 expression and other apoptotic agents such as HtrA2, AIF and caspase-3. Western blot and immunohistochemistry analysis revealed that HAX-1 was expressed at very low levels under normal conditions. Focal cerebral ischemia significantly decreased cytosolic accumulation of HAX-1, induced an upregulation of HtrA2, an upregulation of AIF and activation of caspase-3. Taken together, these results suggested that HAX-1 is probably involved in the pathophysiology of cell death induced by focal ischemia."xsd:string |
| http://purl.uniprot.org/citations/22057932 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11064-011-0641-9"xsd:string |
| http://purl.uniprot.org/citations/22057932 | http://purl.uniprot.org/core/author | "Rami A."xsd:string |
| http://purl.uniprot.org/citations/22057932 | http://purl.uniprot.org/core/author | "Langhagen A."xsd:string |
| http://purl.uniprot.org/citations/22057932 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22057932 | http://purl.uniprot.org/core/name | "Neurochem Res"xsd:string |
| http://purl.uniprot.org/citations/22057932 | http://purl.uniprot.org/core/pages | "548-556"xsd:string |
| http://purl.uniprot.org/citations/22057932 | http://purl.uniprot.org/core/title | "Specific alterations of the HtrA2/HAX-1 ratio in the penumbra upon focal cerebral ischemia in mice."xsd:string |
| http://purl.uniprot.org/citations/22057932 | http://purl.uniprot.org/core/volume | "37"xsd:string |
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