| http://purl.uniprot.org/citations/22059479 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22059479 | http://www.w3.org/2000/01/rdf-schema#comment | "IκB-ζ, an essential inflammatory regulator, is specifically induced by Toll-like receptor ligands or interleukin (IL)-1β by post-transcriptional activation mediated via a 165-nucleotide element in IκB-ζ mRNA. Here, we analyzed the Toll-like receptor-IL-1 receptor signaling components involved in the post-transcriptional regulation of IκB-ζ with mutated estrogen receptor [ER(T2)] fusion proteins. Upon 4-hydroxytamoxifen treatment, the ER(T2) fusion proteins with IL-1 receptor-associated kinase (IRAK)1 and IRAK4 elicited specific activation of a reporter gene for the post-transcriptional regulation of IκB-ζ. The tumor necrosis factor receptor-associated factor (TRAF)6-ER(T2) protein activated nuclear factor-κB, but not post-transcriptional regulation, indicating that activation of IRAK1/4, but not of TRAF6, is sufficient to activate the 165-nucleotide element-mediated post-transcriptional mechanism. Interestingly, the post-transcriptional mechanism was not activated in TRAF6-deficient cells, indicating an essential role for TRAF6. Thus, the signaling pathway leading to nuclear factor-κB activation and the post-transcriptional activation bifurcates at IRAK1, suggesting a new pathway activated by IRAK1."xsd:string |
| http://purl.uniprot.org/citations/22059479 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1742-4658.2011.08416.x"xsd:string |
| http://purl.uniprot.org/citations/22059479 | http://purl.uniprot.org/core/author | "Inoue J."xsd:string |
| http://purl.uniprot.org/citations/22059479 | http://purl.uniprot.org/core/author | "Maruyama T."xsd:string |
| http://purl.uniprot.org/citations/22059479 | http://purl.uniprot.org/core/author | "Ohba T."xsd:string |
| http://purl.uniprot.org/citations/22059479 | http://purl.uniprot.org/core/author | "Muta T."xsd:string |
| http://purl.uniprot.org/citations/22059479 | http://purl.uniprot.org/core/author | "Ariga Y."xsd:string |
| http://purl.uniprot.org/citations/22059479 | http://purl.uniprot.org/core/author | "Truong N.K."xsd:string |
| http://purl.uniprot.org/citations/22059479 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22059479 | http://purl.uniprot.org/core/name | "FEBS J"xsd:string |
| http://purl.uniprot.org/citations/22059479 | http://purl.uniprot.org/core/pages | "211-222"xsd:string |
| http://purl.uniprot.org/citations/22059479 | http://purl.uniprot.org/core/title | "Identification of interleukin-1 receptor-associated kinase 1 as a critical component that induces post-transcriptional activation of IkappaB-zeta."xsd:string |
| http://purl.uniprot.org/citations/22059479 | http://purl.uniprot.org/core/volume | "279"xsd:string |
| http://purl.uniprot.org/citations/22059479 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22059479 |
| http://purl.uniprot.org/citations/22059479 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22059479 |
| http://purl.uniprot.org/uniprot/#_F7CUT1-mappedCitation-22059479 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22059479 |
| http://purl.uniprot.org/uniprot/#_B1AUV9-mappedCitation-22059479 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22059479 |
| http://purl.uniprot.org/uniprot/#_B1AUW1-mappedCitation-22059479 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22059479 |
| http://purl.uniprot.org/uniprot/#_B1AUW6-mappedCitation-22059479 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22059479 |
| http://purl.uniprot.org/uniprot/#_B1AUW8-mappedCitation-22059479 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22059479 |
| http://purl.uniprot.org/uniprot/#_B1AUW9-mappedCitation-22059479 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22059479 |
| http://purl.uniprot.org/uniprot/#_B2RAP9-mappedCitation-22059479 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22059479 |
| http://purl.uniprot.org/uniprot/#_F6TQF4-mappedCitation-22059479 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22059479 |
| http://purl.uniprot.org/uniprot/#_B4E359-mappedCitation-22059479 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22059479 |