| http://purl.uniprot.org/citations/22065573 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22065573 | http://www.w3.org/2000/01/rdf-schema#comment | "The induction of β-interferon (IFN-β) is a key anti-viral response to infection by RNA viruses. Virus-induced expression of IFN-β requires the co-operative action of the transcription factors IRF-3/7, NF-κB, and ATF-2/c-Jun on the IFN-β promoter leading to the orderly recruitment of chromatin remodeling complexes. Although viruses strongly activate NF-κB and promote its binding to the IFN-β promoter, recent studies have indicated that NF-κB is not essential for virus-induced expression of IFN-β. Herein, we examined the role of NF-κB in regulating IFN-β expression in response to the viral-sensing Toll-like receptor 3 (TLR3). Intriguingly pharmacological inhibition of the NF-κB pathway augments late phase expression of IFN-β expression in response to TLR3 stimulation. We show that the negative effect of NF-κB on IFN-β expression is dependent on the induction of the transcriptional repressor protein YinYang1. We demonstrate that the TLR3 ligand polyriboinosinic:polyribocytidylic acid (poly(I:C)) induces expression and nuclear translocation of YinYang1 where it interacts with the IFN-β promoter and inhibits the binding of IRF7 to the latter. Evidence is also presented showing that the NF-κB subunits c-Rel and RelB are the likely key drivers of these negative effects on IFN-β expression. These findings thus highlight for the first time a novel self-regulatory mechanism that is employed by TLR3 to limit the level and duration of IFN-β expression."xsd:string |
| http://purl.uniprot.org/citations/22065573 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m111.250894"xsd:string |
| http://purl.uniprot.org/citations/22065573 | http://purl.uniprot.org/core/author | "Yang S."xsd:string |
| http://purl.uniprot.org/citations/22065573 | http://purl.uniprot.org/core/author | "Moynagh P.N."xsd:string |
| http://purl.uniprot.org/citations/22065573 | http://purl.uniprot.org/core/author | "Miggin S.M."xsd:string |
| http://purl.uniprot.org/citations/22065573 | http://purl.uniprot.org/core/author | "Mitkiewicz M."xsd:string |
| http://purl.uniprot.org/citations/22065573 | http://purl.uniprot.org/core/author | "Siednienko J."xsd:string |
| http://purl.uniprot.org/citations/22065573 | http://purl.uniprot.org/core/author | "Maratha A."xsd:string |
| http://purl.uniprot.org/citations/22065573 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22065573 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/22065573 | http://purl.uniprot.org/core/pages | "44750-44763"xsd:string |
| http://purl.uniprot.org/citations/22065573 | http://purl.uniprot.org/core/title | "Nuclear factor kappaB subunits RelB and cRel negatively regulate Toll-like receptor 3-mediated beta-interferon production via induction of transcriptional repressor protein YY1."xsd:string |
| http://purl.uniprot.org/citations/22065573 | http://purl.uniprot.org/core/volume | "286"xsd:string |
| http://purl.uniprot.org/citations/22065573 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22065573 |
| http://purl.uniprot.org/citations/22065573 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22065573 |
| http://purl.uniprot.org/uniprot/Q92985#attribution-C2166664CE1AF6BC89AFAE91EBF6885E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22065573 |
| http://purl.uniprot.org/uniprot/Q92985#attribution-F5BCC45F3E83F97B9B335E1722ED74F0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22065573 |
| http://purl.uniprot.org/uniprot/Q04864#attribution-C2166664CE1AF6BC89AFAE91EBF6885E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22065573 |
| http://purl.uniprot.org/uniprot/Q04864#attribution-F5BCC45F3E83F97B9B335E1722ED74F0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22065573 |
| http://purl.uniprot.org/uniprot/Q01201#attribution-C2166664CE1AF6BC89AFAE91EBF6885E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22065573 |
| http://purl.uniprot.org/uniprot/Q01201#attribution-F5BCC45F3E83F97B9B335E1722ED74F0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22065573 |
| http://purl.uniprot.org/uniprot/P25490#attribution-F5BCC45F3E83F97B9B335E1722ED74F0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/22065573 |
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