| http://purl.uniprot.org/citations/22069310 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22069310 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-7 plays vital roles in thymocyte development, T cell homeostasis, and the survival of these cells. IL-7 receptor α (IL-7Rα) on thymocytes and T cells is rapidly internalized upon IL-7 ligation. Ephrins (Efns) are cell surface molecules and ligands of the largest receptor kinase family, Eph kinases. We discovered that T cell-specific double gene knock-out (dKO) of Efnb1 and Efnb2 in mice led to reduced IL-7Rα expression in thymocytes and T cells, and that IL-7Rα down-regulation was accelerated in dKO CD4 cells upon IL-7 treatment. On the other hand, Efnb1 and Efnb2 overexpression on T cell lymphoma EL4 cells retarded IL-7Rα down-regulation. dKO T cells manifested compromised STAT5 activation and homeostatic proliferation, an IL-7-dependent process. Fluorescence resonance energy transfer and immunoprecipitation demonstrated that Efnb1 and Efnb2 interacted physically with IL-7Rα. Such interaction likely retarded IL-7Rα internalization, as Efnb1 and Efnb2 were not internalized. Therefore, we revealed a novel function of Efnb1 and Efnb2 in stabilizing IL-7Rα expression at the post-translational level, and a previously unknown modus operandi of Efnbs in the regulation of expression of other vital cell surface receptors."xsd:string |
| http://purl.uniprot.org/citations/22069310 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m111.316414"xsd:string |
| http://purl.uniprot.org/citations/22069310 | http://purl.uniprot.org/core/author | "Han B."xsd:string |
| http://purl.uniprot.org/citations/22069310 | http://purl.uniprot.org/core/author | "Jin W."xsd:string |
| http://purl.uniprot.org/citations/22069310 | http://purl.uniprot.org/core/author | "Luo H."xsd:string |
| http://purl.uniprot.org/citations/22069310 | http://purl.uniprot.org/core/author | "Qi S."xsd:string |
| http://purl.uniprot.org/citations/22069310 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/22069310 | http://purl.uniprot.org/core/author | "Wu Z."xsd:string |
| http://purl.uniprot.org/citations/22069310 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22069310 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/22069310 | http://purl.uniprot.org/core/pages | "44976-44987"xsd:string |
| http://purl.uniprot.org/citations/22069310 | http://purl.uniprot.org/core/title | "Ephrinb1 and Ephrinb2 are associated with interleukin-7 receptor alpha and retard its internalization from the cell surface."xsd:string |
| http://purl.uniprot.org/citations/22069310 | http://purl.uniprot.org/core/volume | "286"xsd:string |
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