| http://purl.uniprot.org/citations/22074830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22074830 | http://www.w3.org/2000/01/rdf-schema#comment | "Dexamethasone (DEX), a potent glucocorticoid, increased the expression of T-cell death associated gene 8 (TDAG8), a proton-sensing G protein-coupled receptor, which is associated with the enhancement of acidic pH-induced cAMP accumulation, in peritoneal macrophages. We explored the role of increased TDAG8 expression in the anti-inflammatory actions of DEX. The treatment of macrophages with either DEX or acidic pH induced the cell death of macrophages; however, the cell death was not affected by TDAG8 deficiency. While DEX inhibited lipopolysaccharide-induced production of tumor necrosis factor-α, an inflammatory cytokine, which was independent of TDAG8, at neutral pH, the glucocorticoid enhanced the acidic pH-induced inhibition of tumor necrosis factor-α production in a manner dependent on TDAG8. In conclusion, the DEX-induced increase in TDAG8 expression is in part involved in the glucocorticoid-induced anti-inflammatory actions through the inhibition of inflammatory cytokine production under the acidic pH environment. On the other hand, the role of TDAG8 in the DEX-induced cell death is questionable."xsd:string |
| http://purl.uniprot.org/citations/22074830 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2011.10.122"xsd:string |
| http://purl.uniprot.org/citations/22074830 | http://purl.uniprot.org/core/author | "Sato K."xsd:string |
| http://purl.uniprot.org/citations/22074830 | http://purl.uniprot.org/core/author | "Takano M."xsd:string |
| http://purl.uniprot.org/citations/22074830 | http://purl.uniprot.org/core/author | "Murata N."xsd:string |
| http://purl.uniprot.org/citations/22074830 | http://purl.uniprot.org/core/author | "Tomura H."xsd:string |
| http://purl.uniprot.org/citations/22074830 | http://purl.uniprot.org/core/author | "Nakakura T."xsd:string |
| http://purl.uniprot.org/citations/22074830 | http://purl.uniprot.org/core/author | "He X.D."xsd:string |
| http://purl.uniprot.org/citations/22074830 | http://purl.uniprot.org/core/author | "Komachi M."xsd:string |
| http://purl.uniprot.org/citations/22074830 | http://purl.uniprot.org/core/author | "Mogi C."xsd:string |
| http://purl.uniprot.org/citations/22074830 | http://purl.uniprot.org/core/author | "Okajima F."xsd:string |
| http://purl.uniprot.org/citations/22074830 | http://purl.uniprot.org/core/author | "Tobo M."xsd:string |
| http://purl.uniprot.org/citations/22074830 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22074830 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/22074830 | http://purl.uniprot.org/core/pages | "627-631"xsd:string |
| http://purl.uniprot.org/citations/22074830 | http://purl.uniprot.org/core/title | "Involvement of proton-sensing receptor TDAG8 in the anti-inflammatory actions of dexamethasone in peritoneal macrophages."xsd:string |
| http://purl.uniprot.org/citations/22074830 | http://purl.uniprot.org/core/volume | "415"xsd:string |
| http://purl.uniprot.org/citations/22074830 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22074830 |
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| http://purl.uniprot.org/uniprot/Q3UZ41 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22074830 |