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http://purl.uniprot.org/citations/22078452http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Aim

To study possible association between three single nucleotide polymorphisms (-597G/A, -572C/G and -174G/C) of interleukin-6 (IL-6) gene promoter and breast cancer.

Methods

Genomic DNA was isolated from the venous blood leukocytes from 176 unrelated patients with breast cancer and 200 healthy unrelated females (control group). Polymorphisms of -597G/A, -572C/G and -174G/C, were genotyped by PCR-restriction fragment length polymorphisms (PCR-RFLP). SPSS 11.5 software was employed for statistical analysis and the association of IL-6 polymorphisms with breast cancer was evaluated by x(2); test.

Results

There was significant differences in both allele and genotype frequencies of -572C/G in case group compared with control group. The allele G of -572C/G was significantly higher in cancer patients than the controls(x(2);=15.438, P<0.01).

Conclusion

There is an association between -572C/G polymorphism and breast cancer risk. The females with G allele of -572C/G are susceptible to breast cancer compared with non-carrying females."xsd:string
http://purl.uniprot.org/citations/22078452http://purl.uniprot.org/core/author"Wang H."xsd:string
http://purl.uniprot.org/citations/22078452http://purl.uniprot.org/core/author"Zhang D.J."xsd:string
http://purl.uniprot.org/citations/22078452http://purl.uniprot.org/core/author"Li Y.P."xsd:string
http://purl.uniprot.org/citations/22078452http://purl.uniprot.org/core/author"He K.L."xsd:string
http://purl.uniprot.org/citations/22078452http://purl.uniprot.org/core/author"Lv Y.G."xsd:string
http://purl.uniprot.org/citations/22078452http://purl.uniprot.org/core/date"2011"xsd:gYear
http://purl.uniprot.org/citations/22078452http://purl.uniprot.org/core/name"Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi"xsd:string
http://purl.uniprot.org/citations/22078452http://purl.uniprot.org/core/pages"1220-1222"xsd:string
http://purl.uniprot.org/citations/22078452http://purl.uniprot.org/core/title"[Association between polymorphisms of interleukin-6 gene promoter and breast cancer]."xsd:string
http://purl.uniprot.org/citations/22078452http://purl.uniprot.org/core/volume"27"xsd:string
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