| http://purl.uniprot.org/citations/22078496 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22078496 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22078496 | http://www.w3.org/2000/01/rdf-schema#comment | "MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate gene expression. Among these, members of the let-7 miRNA family control many cell-fate determination genes to influence pluripotency, differentiation, and transformation. Lin28 is a specific, posttranscriptional inhibitor of let-7 biogenesis. We report crystal structures of mouse Lin28 in complex with sequences from let-7d, let-7-f1, and let-7 g precursors. The two folded domains of Lin28 recognize two distinct regions of the RNA and are sufficient for inhibition of let-7 in vivo. We also show by NMR spectroscopy that the linker connecting the two folded domains is flexible, accommodating Lin28 binding to diverse let-7 family members. Protein-RNA complex formation imposes specific conformations on both components that could affect downstream recognition by other processing factors. Our data provide a molecular explanation for Lin28 specificity and a model for how it regulates let-7."xsd:string |
| http://purl.uniprot.org/citations/22078496 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2011.10.020"xsd:string |
| http://purl.uniprot.org/citations/22078496 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2011.10.020"xsd:string |
| http://purl.uniprot.org/citations/22078496 | http://purl.uniprot.org/core/author | "Chen C."xsd:string |
| http://purl.uniprot.org/citations/22078496 | http://purl.uniprot.org/core/author | "Chen C."xsd:string |
| http://purl.uniprot.org/citations/22078496 | http://purl.uniprot.org/core/author | "Nam Y."xsd:string |
| http://purl.uniprot.org/citations/22078496 | http://purl.uniprot.org/core/author | "Nam Y."xsd:string |
| http://purl.uniprot.org/citations/22078496 | http://purl.uniprot.org/core/author | "Gregory R.I."xsd:string |
| http://purl.uniprot.org/citations/22078496 | http://purl.uniprot.org/core/author | "Gregory R.I."xsd:string |
| http://purl.uniprot.org/citations/22078496 | http://purl.uniprot.org/core/author | "Sliz P."xsd:string |
| http://purl.uniprot.org/citations/22078496 | http://purl.uniprot.org/core/author | "Sliz P."xsd:string |
| http://purl.uniprot.org/citations/22078496 | http://purl.uniprot.org/core/author | "Chou J.J."xsd:string |
| http://purl.uniprot.org/citations/22078496 | http://purl.uniprot.org/core/author | "Chou J.J."xsd:string |
| http://purl.uniprot.org/citations/22078496 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22078496 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/22078496 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/22078496 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/22078496 | http://purl.uniprot.org/core/pages | "1080-1091"xsd:string |
| http://purl.uniprot.org/citations/22078496 | http://purl.uniprot.org/core/pages | "1080-1091"xsd:string |
| http://purl.uniprot.org/citations/22078496 | http://purl.uniprot.org/core/title | "Molecular basis for interaction of let-7 microRNAs with Lin28."xsd:string |
| http://purl.uniprot.org/citations/22078496 | http://purl.uniprot.org/core/title | "Molecular basis for interaction of let-7 microRNAs with Lin28."xsd:string |
| http://purl.uniprot.org/citations/22078496 | http://purl.uniprot.org/core/volume | "147"xsd:string |
| http://purl.uniprot.org/citations/22078496 | http://purl.uniprot.org/core/volume | "147"xsd:string |