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http://purl.uniprot.org/citations/22078795http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22078795http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To compare the differential expression of 15-lipoxygenase (15-LO) isoenzymes, 15-LO-1 and 15-LO-2 in preeclampsia (PE), and normal pregnancy and its metabolite 15-hydroxyeicosatetraenoic acid (15-HETE) on the vasoconstriction of human umbilical artery (HUA) rings.

Study design

We performed western blotting and isometric tension studies and t-test analysis on data from 6 women with normal pregnancy and 8 women with PE.

Results

Expressions of 15-LO-1 and 15-LO-2 in placentas and HUA rings in PE increased more than that in normal groups (P<0.01). 15-HETE increased HUA rings tension in a dose-dependence manner, which were significantly greater in PE than in normal pregnant controls (P<0.01). However, the constriction of HUA rings was completely eliminated by 2-aminoethoxydiphenyl borate (2-APB) in both normal pregnancy and PE (P<0.01) and attenuated partly by nifedipine in dose-dependence in normal pregnancy (10(-8)mol/L P>0.05; 10(-7), 10(-6)mol/L P<0.05) and in PE (P<0.01).

Conclusion

PE upregulates 15-LO pathway via 15-HETE, which increased intercellular calcium level to cause constriction of HUA rings."xsd:string
http://purl.uniprot.org/citations/22078795http://purl.org/dc/terms/identifier"doi:10.1016/j.plefa.2011.10.006"xsd:string
http://purl.uniprot.org/citations/22078795http://purl.uniprot.org/core/author"Cai L."xsd:string
http://purl.uniprot.org/citations/22078795http://purl.uniprot.org/core/author"Sun J."xsd:string
http://purl.uniprot.org/citations/22078795http://purl.uniprot.org/core/author"Wang Y."xsd:string
http://purl.uniprot.org/citations/22078795http://purl.uniprot.org/core/author"Zhu D."xsd:string
http://purl.uniprot.org/citations/22078795http://purl.uniprot.org/core/author"Zheng J."xsd:string
http://purl.uniprot.org/citations/22078795http://purl.uniprot.org/core/author"An Y."xsd:string
http://purl.uniprot.org/citations/22078795http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22078795http://purl.uniprot.org/core/name"Prostaglandins Leukot Essent Fatty Acids"xsd:string
http://purl.uniprot.org/citations/22078795http://purl.uniprot.org/core/pages"79-84"xsd:string
http://purl.uniprot.org/citations/22078795http://purl.uniprot.org/core/title"Preeclampsia activates 15-lipoxygenase and its metabolite 15-hydroxyeicosatetraenoic acid enhances constriction in umbilical arteries."xsd:string
http://purl.uniprot.org/citations/22078795http://purl.uniprot.org/core/volume"86"xsd:string
http://purl.uniprot.org/citations/22078795http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/22078795
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