| http://purl.uniprot.org/citations/22080244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22080244 | http://www.w3.org/2000/01/rdf-schema#comment | "E-cadherin (E-CD) inactivation with loss of E-CD-mediated cell adhesion is the hallmark of lesions of the lobular phenotype. E-CD is typically absent by immunohistochemistry in both lobular carcinoma in situ (LCIS) and invasive lobular lesions, suggesting it occurs early in the neoplastic process. In laboratory models, downstream post-transcriptional modifiers such as TWIST and SNAIL contribute to the dissociation of the intracellular component of the cadherin-catenin complex (CCC), resulting in tumor progression and invasion. We hypothesized that complete CCC dissociation may play a role in lobular neoplasia progression. Here we explore the relationship between loss of E-CD and dissociation of the CCC in pure LCIS and LCIS associated with invasive cancer. Fresh-frozen tissues were obtained from 36 patients undergoing mastectomy for pure LCIS (n = 11), LCIS with ILC (n = 18) or LCIS with IDC (n = 7). Individual lesions were subject to laser-capture microdissection and gene-expression analysis (Affymetrix HG-U133A 2.0). Immunohistochemistry for ER,PR,HER2, E-CD,N-CD,α-,β-, and phosphoβ-catenin, TWIST, and SNAIL were evaluated in normal, in situ, and invasive components from matched formalin-fixed paraffin-embedded samples (n = 36). CCC-dissociation was defined as negative membranous E-CD, α- and β-catenin expression. E-CD was negative in all LCIS and ILC lesions, and positive in all normal and IDC lesions. Membranous α and β-catenin expressions decreased with the transition from LCIS to ILC (pure LCIS 82%; LCIS w/ILC 28%; ILC 0%), while TWIST expression increased (pure LCIS low; LCIS w/ILC moderate; ILC high). Gene expression paralleled IHC-staining patterns with a stepwise downregulation of E-CD, α and β-catenins from normal to LCIS to invasive lesions, and increasing expression of TWIST from normal to LCIS to ILC. Loss of E-CD expression is an early event in lobular neoplasia. Decreasing membranous catenin expression in tandem with increasing levels of TWIST across the spectrum of lobular lesions suggests that CCC dissociation is a progressive process."xsd:string |
| http://purl.uniprot.org/citations/22080244 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10549-011-1860-0"xsd:string |
| http://purl.uniprot.org/citations/22080244 | http://purl.uniprot.org/core/author | "Qin L.X."xsd:string |
| http://purl.uniprot.org/citations/22080244 | http://purl.uniprot.org/core/author | "Morrow M."xsd:string |
| http://purl.uniprot.org/citations/22080244 | http://purl.uniprot.org/core/author | "Giri D."xsd:string |
| http://purl.uniprot.org/citations/22080244 | http://purl.uniprot.org/core/author | "Brogi E."xsd:string |
| http://purl.uniprot.org/citations/22080244 | http://purl.uniprot.org/core/author | "Andrade V.P."xsd:string |
| http://purl.uniprot.org/citations/22080244 | http://purl.uniprot.org/core/author | "Arroyo C.D."xsd:string |
| http://purl.uniprot.org/citations/22080244 | http://purl.uniprot.org/core/author | "King T.A."xsd:string |
| http://purl.uniprot.org/citations/22080244 | http://purl.uniprot.org/core/author | "Morrogh M."xsd:string |
| http://purl.uniprot.org/citations/22080244 | http://purl.uniprot.org/core/author | "Paik W."xsd:string |
| http://purl.uniprot.org/citations/22080244 | http://purl.uniprot.org/core/author | "Sakr R.A."xsd:string |
| http://purl.uniprot.org/citations/22080244 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22080244 | http://purl.uniprot.org/core/name | "Breast Cancer Res Treat"xsd:string |
| http://purl.uniprot.org/citations/22080244 | http://purl.uniprot.org/core/pages | "641-652"xsd:string |
| http://purl.uniprot.org/citations/22080244 | http://purl.uniprot.org/core/title | "Cadherin-catenin complex dissociation in lobular neoplasia of the breast."xsd:string |
| http://purl.uniprot.org/citations/22080244 | http://purl.uniprot.org/core/volume | "132"xsd:string |
| http://purl.uniprot.org/citations/22080244 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22080244 |
| http://purl.uniprot.org/citations/22080244 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22080244 |
| http://purl.uniprot.org/uniprot/#_A0A0E3XJU3-mappedCitation-22080244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22080244 |
| http://purl.uniprot.org/uniprot/#_A0A0U2ZQU7-mappedCitation-22080244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22080244 |
| http://purl.uniprot.org/uniprot/#_A0A140HMB1-mappedCitation-22080244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22080244 |
| http://purl.uniprot.org/uniprot/#_A0A384MDY0-mappedCitation-22080244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22080244 |
| http://purl.uniprot.org/uniprot/#_B3KSR8-mappedCitation-22080244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22080244 |